Epidemiology study of patients with suspected or diagnosed Celiac Disease
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1
Hospital General Universitario Gregorio Marañón, Immunology, Spain
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2
Hospital Clínico San Carlos, Immunology, Spain
Background: Celiac disease (CD) affects 0.5% of the population and is more prevalent in women than men (3:1). Regarding age, there are two peaks, 1-3 and 30-50 years, which is higher the number of cases diagnosed.
Mehods: 2590 patients (985 children and 1605 adults) with suspicions or diagnostic of CD were included in the study between January-May 2013. Prevalence of CD markers (anti-tissue transglutaminase (tTG) IgA and IgG and anti-deamidated gliadin peptide (PDG) IgG antibodies), clinical features and biopsy were evaluated.
Results: Prevalence of positive markers of CD in children was 15% (148/985): 148 PDG IgG, 39 tTG IgA and 15 tTG IgG; 73 were female and 75 male. Positive biopsies (Marsh classification) were 23/52 (12/23: 1-3 years-old and 11/23: 3-17 years-old children). Main Symptoms: anaemia, pondostatural delay, malabsorption syndrome, chronic diarrhea, abdominal pain and constipation. Prevalence of positive markers of CD in adults was 6,9% (111/1605): 111 PDG IgG and 12 tTG IgA, 74 were female and 37 male. Positive biopsies were 18/35 (7/18: 18-29 years-old, 9/18 in 30-50 years-old and 2/18: 51-87 years-old adults). In addition to the classic symptoms these patients had polyneuropathies, liver diseases, polyarthralgia, pruritus, irritability and recurrent miscarriage.
Conclusions: CD in children showed the same prevalent in both gender, affecting more between ages 1-3 years and predominantly gastrointestinal symptoms. However, in adults is more common in female, the diagnosis is made mainly before 50 years and the symptoms are more variable. Screening of CD should be performed only with antiDGP IgG antibody determination.
References
1. Mariné M, Farre C, et al. The prevalence of coeliac disease is significantly higher in children compared with adults. Aliment Pharmacol Ther 2011; 33:477–486.
2. Evans KE, Hadjivassiliou M, Sanders DS. Recognising coeliac disease in Eastern Europe: the hidden epidemic in our midst? J Gastrointestin Liver Dis 2011; 20:117–118.
3. Roshan B, Leffler DA, et al. The incidence and clinical spectrum of refractory celiac disease in a North American referral center. Am J Gastroenterol 2011; 106:923–928.
4. Sugai E, Hwang HJ, Vázquez H, et al. New serology assays can detect gluten sensitivity among enteropathy patients seronegative for antitissue transglutaminase. Clin Chem 2010; 56:661–665.
Keywords:
Epidemiology study,
Celiac Disease,
CD markers,
Biopsy,
Clinical features
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Herráiz-Nicuesa
L,
Martín
LM,
Sánchez-Ramón
S and
Rodriguez-Mahou
M
(2013). Epidemiology study of patients with suspected or diagnosed Celiac Disease.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.01043
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Received:
09 Jul 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Mrs. Laura Herráiz-Nicuesa, Hospital General Universitario Gregorio Marañón, Immunology, Madrid, Spain, laura.herraiz@salud.madrid.org