Carotid intima media thickness, plaques , IL-6 and disease activity in rheumatoid arthritis patients among Egyptians
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1
Benha university Hospital ,Benha faculty of medicine, Rheumatology and rehabilitation, Egypt
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2
Benha university faculty of medicine, Radiology, Egypt
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3
Benha university faculty of medicine, Clinical pathology, Egypt
Abstract:
Aim: To study the extent of the carotid intima-media thickness (IMT), plaques and the most predicting subclinical atherosclerotic variables (IL-6) in different grades of disease activity in rheumatoid patients .
Patients and methods: 120 RA patients, sex and age matched controls were recruited at rheumatology department Benha university Egypt. They were 98 females and 22 males. Their ages ranged between 25 and 66 years and disease duration from 1 to 26 years with a mean of 9.7± 6.04 .Cardiovascular (CV) risk factors, RA characteristics were recorded. cartoid (IMT) and plaques were assessed in RA patients and controls with high resolution B-mode ultrasound ultrasound (US).
Results: The mean value of IMT in the patients was 1.18± 0.98 mm while in the controls was 0.63± 0.18 mm which show highly statistically significant between two groups(p<0.001). The incidence of carotid plaques in our patients were significantly higher compared to controls. There were statistically significant correlations (P<0.05) between IMT of the CCA ,plaques in RA and disease related variables; articular index, CRP, ESR, BMI,T cholesterol, HDL, TG, hemoglobin leve l,and highly significant correlations (P<0.001) were found in relation to IL-6, LDL, disease duration, Larsen score, and pain severity.
Conclusion: These results support that RA patient have an ultrasonic marker (plaques and intima media thickness) of early atherosclerosis and these findings correlate significantly with disease activity and IL-6 levels, IL-6 being one of the most predictive marker of these findings.
Acknowledgements
I would like to thank my colleagues, my department and the cooperation of the patients who accepted to be enrolled in this study
Keywords:
Carotid intima media thickness,
plaques,
IL6,
disease activity,
Rheumatoid arthritis
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Algergawy
SA,
Shamsaldeen
A,
Rifaat
M and
Belal
K
(2013). Carotid intima media thickness, plaques , IL-6 and disease activity in rheumatoid arthritis patients among Egyptians.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.01104
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Received:
29 Jul 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Prof. Shereen A Algergawy, Benha university Hospital ,Benha faculty of medicine, Rheumatology and rehabilitation, Benha, Egypt, shereen.algergawy@fmed.bu.edu.eg