Online 3D simulation of extracellular recordings with morphologically reconstructed neurons
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1
Bernstein Center for Computational Neuroscience, BCCN-B, Germany
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2
Berlin Institute of Technology, School for Electrical Engineering and Computer Science, Germany
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3
Norwegian University of Life Sciences, Department of Mathematical Sciences and Technology, Norway
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4
Max Planck Inst. for Biol. Cybernetics, MPI, Germany
Extracellular recordings are a key tool to study the activity of neurons in vivo. Especially in the case of experiments with behaving animals, however, the tedious procedure of electrode placement can take a considerable amount of expensive and restricted experimental time. Furthermore, due to tissue drifts and other sources of variability in the recording setup, the position of the electrodes with respect to the neurons under study can change, causing low recording quality. Here, we developed a system online simulation of extracellular recordings that allows for feedback from electrode positioning systems.
The simulator is based on realistically reconstructed 3D neurons. The shape of the extracellular waveform is estimated from their morphology for every point on a 3D grid around the neurons. If a recording device is close to a neuron, the corresponding waveform for its spikes is calculated from that grid by interpolating the waveforms of the adjacent grid positions. This way we can simulate a realistic recording environment in which an unconstrained movement of electrodes and neurons and an interaction with a positioning system and online spike sorter is possible.
Acknowledgements
This work was supported by DFG GRK 1589/1 and the German Federal Ministry of Education and Research (BMBF) with the grants 01GQ0743 and 01GQ0410 and by the Research Council of Norway (eScience,NeuroNor).
Keywords:
computational neuroscience
Conference:
Bernstein Conference on Computational Neuroscience, Berlin, Germany, 27 Sep - 1 Oct, 2010.
Presentation Type:
Poster Abstract
Topic:
Bernstein Conference on Computational Neuroscience
Citation:
Franke
F,
Meier
P,
Natora
M,
Hagen
E,
Pettersen
KH,
Lindén
H,
Einevoll
GT,
Munk
MH and
Obermayer
KH
(2010). Online 3D simulation of extracellular recordings with morphologically reconstructed neurons.
Front. Comput. Neurosci.
Conference Abstract:
Bernstein Conference on Computational Neuroscience.
doi: 10.3389/conf.fncom.2010.51.00128
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Received:
23 Sep 2010;
Published Online:
23 Sep 2010.
*
Correspondence:
Mr. Felix Franke, Bernstein Center for Computational Neuroscience, BCCN-B, Berlin, Germany, felfranke@googlemail.com