Comparative analysis of event-related potentials and oscillations during auditory oddball task in parkinson’s patients with parkin gene mutations and idiopathic parkinson’s disease
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1
Istanbul University, Istanbul Faculty of Medicine,, Türkiye
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2
Acibadem University, Faculty of Medicine, Türkiye
Parkinson’s disease (PD) is characterized by motor impairment, but clinical evidence suggests that PD patients develop deficits across many cognitive functions. Parkin (PARK2) gene mutations are most common cause of the autosomal recessive form of PD. We aimed to compare the cognitive decline of patients with parkin gene mutation and idiopathic PD patients by event-related potentials (ERPs) and event related oscillations (EROs) during auditory oddball task. Experiments were carried out on the following four groups of subjects: control (n = 25), Parkin mutation (PM-PD, n = 15), early onset (EO-PD, n = 25) and late onset (LO-PD, n = 25) idiopathic PD. Both P3 amplitudes and evoked delta (2-4 Hz, 100-400 ms) power of the target condition were significantly reduced in EO-PD and LO-PD groups compared with the controls, while no significant difference was observed for the PM-PD group. However, both total delta (2-4 Hz, 100-400 ms) and total theta (5-12 Hz 50-250 ms) powers in target responses were significantly reduced in all three PD groups. While the absence of significant ERP changes in PM-PD group is in-line with the literature that reports relatively lighter cognitive decline in relatively younger PM-PD patients, the in-depth time-frequency analysis of the brain electrical responses shows that a significant change can be observed in terms of induced (non-phase-locked) EROs. This can be a starting point for understanding the neural mechanisms that are affected in this subgroup of Parkinson's patients.
Keywords:
brain oscillations,
Parkison
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Quantitative Analysis of EEG, MEG & Brain Oscillations
Citation:
Uslu
A,
Ergen
M,
Demirci
H,
Hanagasi
H and
Demiralp
T
(2011). Comparative analysis of event-related potentials and oscillations during auditory oddball task in parkinson’s patients with parkin gene mutations and idiopathic parkinson’s disease.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00147
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Received:
17 Nov 2011;
Published Online:
28 Nov 2011.
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Correspondence:
Dr. Atilla Uslu, Istanbul University, Istanbul Faculty of Medicine,, Isntabul, Türkiye, atillauslu_itf@hotmail.com