A gender-specific association of interleukin-1 receptor antogonist (IL1Ra) polymorphism with schizophrenia susceptibility
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1
higher institute of biotechnology, Tunisia
Objective: Recent genetic studies have revealed that the IL1 gene complex is associated with schizophrenia in the Caucasian population; however, data from north-african population are underrepresented. In order to further assess the role of IL1Ra in schizophrenia, we examined a functional multiallelic polymorphism localized in the intron 2 of this receptor gene associated with altered level of IL1Ra.
Methods: In the present case/controlled study, we have analyzed the (86pb)n polymorphism of the IL1-RN gene by PCR genotyping in 247 patients with schizophrenia and 150 healthy controls from the Tunisian population.
Results: We showed that the frequencies of IL1RN*2/2 genotype and allele 2 were higher in the patient group vs. the control one, and the difference was statistically significant (13.8% vs. 3.3%, p=10-3, OR=5.8 and 35.2% vs. 20.3%, p=10-4, OR=2.1 respectively). When we have evaluated the association between this genetic polymorphism and the clinical variables of schizophrenia, we found that the frequency of the 2/2 genotype and the allele 2 were significantly higher in the male patients group (p=5.10-4 and p=10-4 respectively) compared to the male control group, indicating a substantially increased risk for sex-onset schizophrenia with inheritance of the IL1RN2 allele.
Conclusion: the intron 2 polymorphism in IL1RN or a genetic polymorphism at proximity seems to be associated specifically with schizophrenia in the Tunisian male population.
Acknowledgements
We thank the staff of the department of Blood bank and Psychiatry of the CHU F. Bourguiba of Monastir for providing samples and clinical informations.
Keywords:
Single Nucleotide Polymorphisms (SNP),
Interleukin1,
Neuroinflammation,
Schizophrenia,
case-control study
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Bel Hadj Jrad
BT and
Ben Nejma
M
(2013). A gender-specific association of interleukin-1 receptor antogonist (IL1Ra) polymorphism with schizophrenia susceptibility.
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00007
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Received:
18 Mar 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Prof. Besma T Bel Hadj Jrad, higher institute of biotechnology, monastir, Tunisia, bbhj2002@yahoo.fr