Grey matter reductions in children with congenital hypothyroidism: A voxel-based morphometry study
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1
The Hospital for Sick Children, Canada
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2
University of Toronto, Canada
Congenital hypothyroidism (CH) is a disease of newborns caused by lack of thyroid hormone (TH) which is essential for normal brain development. This study used voxel-based morphometry to determine whether CH have reductions in grey matter that can be attributed to timing of TH loss and later cognitive problems. Methods: Studied were 15 CH and 21 typically developing controls aged 10-15 years. In SPM5, T1-weighted images were normalized to MNI template, segmented into grey matter, white matter and CSF, and smoothed (FWHM 8mm). Using 2 sample t-tests (FDR p<.05), statistical parametric maps revealed significant clusters of reduced grey matter in CH. Results: CH showed significant reductions in grey matter in frontal lobes, caudate nucleus, supplementary motor area, and visual cortex, bilaterally. In CH, more severe disease at diagnosis was associated with reductions in visual cortex, frontal lobes, and anterior cingulated. Longer time to TH normalization was associated with reductions in left hippocampus and bilateral supplementary motor area. Affected areas predicted poor performance on cognitive tasks as expected. Conclusions: In CH, early TH deficiency leads to reduced brain grey matter density with affected regions reflecting timing of TH deficiency and contributing to compromised cognitive abilities in adolescence.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Frontal Lobe Development
Citation:
Skocic
J and
Rovet
J
(2010). Grey matter reductions in children with congenital hypothyroidism: A voxel-based morphometry study.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00077
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Received:
29 Jun 2010;
Published Online:
29 Jun 2010.
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Correspondence:
J. Rovet, The Hospital for Sick Children, Toronto, Canada, joanne.rovet@sickkids.ca