Stress and neuro-hormonal control of food intake
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1
Lab. Génie Biologique, Morocco
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2
CRN2M, France
Stressful events are related with many dysfunctions leading to homeostasis disruption. For example, exposure to stress has been argued to produce maladaptive behavioral states, and many of the brain regions associated with stressor responding also mediate these affected behaviors. The effect of stress has been sown to act via the activation of the hypothalamo-hypophyseo-adrenocorticotropin (HPA) axis. Furthermore, many neurochemical pathways seemed to respond or to be affected by stress. This especially evidenced for those involved in the control of food intake in that several stressful situations can lead to a pathogenesis of anorexia. In this study, we analyzed the effects of acute immobilization stress (IS) on the expression of two major neuropeptide regulators of food intake, in the hypothalamus and the dorsal vagal complex (DVC). The expression of the neuropeptide Y (NPY) and cocaine- and amphetamine- regulated transcript (CART) displayed generally significant increases in stressed rats compared to controls, although with differential patterns. Thus, they rapidly increase in hypothalamus at the end of the stress session, whereas in the DVC th expression rise significantly at 24h post-stress and decline afterwards; it remains significantly higher in stressed than in controls for NPY whereas CART was down-regulated after 48h post-stress. These post stress alterations have generally linked to the response of the HPA axis and its recovery after IS as has been suggested. These results will be discussed with reference to brain plasticity.
Conference:
3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009.
Presentation Type:
Poster Presentation
Topic:
Stress
Citation:
Najimi
M,
Chigr
F,
Rachidi
F,
Tardivel
C and
Moyse
E
(2009). Stress and neuro-hormonal control of food intake.
Front. Neurosci.
Conference Abstract:
3rd Mediterranean Conference of Neuroscience .
doi: 10.3389/conf.neuro.01.2009.16.144
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Received:
25 Nov 2009;
Published Online:
25 Nov 2009.
*
Correspondence:
Mohamed Najimi, Lab. Génie Biologique, Beni-Mellal, Morocco, mnajimi1@fstbm.ac.ma