Dorsal hippocampal involvement in different forms of memory retrieval
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1
Cardiff University, School of Psychology, United Kingdom
Two studies examined the role of the dorsal hippocampus in retrieval of configural memories involving which auditory stimulus (tone or clicker) was presented where (spotted or checked context) and when (morning or afternoon). We developed a novel procedure in which rats were required to learn that in the morning the tone occurred in the spotted context and the clicker in the checked context, and in the afternoon the tone occurred in the checked context and the clicker in the spotted context. Configural knowledge was revealed by pairing the tone with shock in a third context at midday, and showing that the configurations paired with the tone (morning and spotted context; afternoon and checked context) provoked the most fear at test. In Experiment 1, inactivation of the dorsal hippocampus with muscimol (a gamma-Aminobutyric acid agonist) microinfusions at test abolished retrieval of configural memories involving which stimulus was presented where and when. In Experiment 2, identical hippocampal inactivation at test, however, did not affect retrieval of which auditory stimulus was presented where (spotted or checked context) or which stimulus was presented when (morning or afternoon). Our results provide important evidence that the hippocampus is critical for the retrieval of configural memories involving what-where-when, but not other memories involving the same constituents i.e. what-where or what-when). These results are particularly consistent with the view that the hippocampus is necessary for the retrieval of configural memories with episodic content.
Conference:
41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster presentations
Citation:
Iordanova
M,
Good
M,
Burnett
D and
Honey
R
(2009). Dorsal hippocampal involvement in different forms of memory retrieval.
Conference Abstract:
41st European Brain and Behaviour Society Meeting.
doi: 10.3389/conf.neuro.08.2009.09.178
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Received:
10 Jun 2009;
Published Online:
10 Jun 2009.
*
Correspondence:
Mihaela Iordanova, Cardiff University, School of Psychology, Cardiff, United Kingdom, iordanovamd@cardiff.ac.uk