P3b amplitude reduction is not progressive over the course of schizophrenia: a longitudinal study in first-episode patients
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1
University of Istanbul, Türkiye
Auditory P3b amplitude reduction is a widely replicated finding in schizophrenia. The findings of cross-sectional studies examining whether the P3b is reduced with longer illness duration are contraversial. In this study longitudinal data of first-episode schizophrenia patients were evaluated to determine whether P3b deterioration is increased with illness chronicity, consistent with a progressive pathophysiological process. Subject groups comprised 11 patients with schizophrenia (10 women) and 10 age- and education-matched healthy controls (5 women). Schizophrenia patients and healthy controls were tested on two occasions with mean inter-test intervals of 6.2+/-0.8 and 5.7+/-1.3 years, respectively. Schizophrenia patients were at the post-acute phase of their first-episode during the initial testing. P3b was elicited during an oddball paradigm consisted of standard (1000 Hz, probability 0.8) and target stimuli (1500 Hz, probability 0.2). Groups showed the expected parietocentral distribution of P3b (p=0.001). P3b amplitudes were reduced in patients compared to controls (p=0.01). No difference in P3b amplitudes was observed between the two testings. The groups did not differ for the P3b amplitude differences between the two testings, indicating that there is no further reduction in P3b with the increase in illness duration. Our results showed that P3b reduction is present in both first-episode and chronic phases of schizophrenia and that the deterioration in P3b processes are not progressive over the course of illness. To our knowledge the present study is the first to report on P3b longitudinally in schizophrenia patients with a relatively long inter-test interval.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Oral Presentation
Topic:
Neuropsychiatric Disorders
Citation:
Devrim-Üçok
M,
Keskin-Ergen
H and
Üçok
A
(2008). P3b amplitude reduction is not progressive over the course of schizophrenia: a longitudinal study in first-episode patients.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.393
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Received:
17 Dec 2008;
Published Online:
17 Dec 2008.
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Correspondence:
Müge Devrim-Üçok, University of Istanbul, Istanbul, Türkiye, devrim@istanbul.edu.tr