A change of meaning causes connectivity changes within higher levels of the auditory cortical heirarchy
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1
UCL Division of Psychology and Language Sciences, United Kingdom
Early cortical processing of speech and non-speech sounds occurs bilaterally within primary auditory cortex and surrounding regions of the superior temporal gyrus; however, the manner in which these regions interact during speech and non-speech processing is not well understood. Here, we investigate the underlying neuronal architecture of the auditory system with magnetoencephalography and a mismatch paradigm. We used a spoken word as a repeating ‘standard’ and periodically introduced three ‘oddball’ stimuli that differed in the frequency spectrum of the word’s vowel. The closest deviant was perceived as the same vowel as the standard, whereas the other two deviants were perceived as belonging to different vowel categories. The neuronal responses to these vowel stimuli were compared to responses elicited by perceptually matched tone stimuli under the same paradigm. For both speech and tones, deviant stimuli induced coupling changes within the same bilateral temporal lobe system. However, vowel oddball effects increased coupling within the left posterior superior temporal gyrus, whereas perceptually equivalent non-speech oddball effects increased coupling within right primary auditory cortex. Thus, we show a dissociation in neuronal interactions, occurring at both different hierarchal levels of the auditory system (superior temporal versus primary auditory cortex) and in different hemispheres (left versus right). This hierarchical specificity depends on whether auditory stimuli are embedded in a perceptual context (i.e., a word). Furthermore, our lateralization results suggest left hemisphere specificity for the processing of phonological stimuli, regardless of their elemental (i.e., spectrotemporal) characteristics.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster Presentations
Citation:
Schofield
T,
Iverson
P,
Kiebel
S,
Stephan
KE,
Kilner
J,
Friston
KJ,
TCrinion
J,
Price
CJ and
Leff
AP
(2009). A change of meaning causes connectivity changes within higher levels of the auditory cortical heirarchy.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.113
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Received:
26 Mar 2009;
Published Online:
26 Mar 2009.
*
Correspondence:
Thomas Schofield, UCL Division of Psychology and Language Sciences, London, United Kingdom, thomasschofield76@yahoo.co.uk