• Info
  • Home
  • About
  • Editorial Board
  • Archive
  • Research Topics
  • View Some Authors
  • Review Guidelines
  • Subscribe to Alerts
  • Search
  • Article Type

    Publication Date

  • Author Info
  • Why Submit?
  • Fees
  • Article Types
  • Author Guidelines
  • Submission Checklist
  • Contact Editorial Office
  • Submit Manuscript
Start date should be earlier than end date. OK Please enter the date in dd/mm/yyyy format or use the calendar icon to the left of the date field.

Research Topic

Share 0
Like 0

Targeting anaplastic lymphoma kinase in cancers and beyond

Topic Editors:

Giuseppe Giaccone, Georgetown University, USA
Yisong Wang, National Cancer Institute, National Institute of Health, USA

Submission Closed.

Activation of anaplastic lymphoma kinase (ALK) through chromosome rearrangement, amplification, mutation or deregulated expression has been found in anaplastic large cell lymphomas, inflammatory myofibroblastic tumors, rhabdomyosarcomas, non-small cell lung cancers (NSCLC), glioblastomas, neuroblastomas, breast cancers and others. Although preclinical studies with ALK inhibitors (small molecules, siRNAs and selective ribozymes) have yielded promising data, only a few of the inhibitors reached clinical trials. Crizotinib, a c-Met and ALK inhibitor, has recently demonstrated high objective response rates in ALK-positive NSCLC patients but resistance seems inescapable. We propose to launch a Research Topic under Frontiers in Cancer Molecular Targets and Therapeutics to address questions related to ALK signaling in cancer, mechanisms of ALK inhibitor action and resistance, development and characterization of next generation inhibitors against ALK, its downstream molecules and ligands, novel technologies for ALK rearrangement detection, and innovative strategies for target-specific treatment of ALK-positive cancer patients. Basic, translational, clinical research papers and reviews are all welcome.

Share 0
Like 0

About Frontiers Research Topics

img

Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

© 2007 - 2014 Frontiers Media S.A. All Rights Reserved