Defying the stereotype: non-canonical roles of the peptide hormones guanylin and uroguanylin
- Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
The peptide hormones uroguanylin and guanylin have been traditionally thought to be mediators of fluid–ion homeostasis in the vertebrate intestine. They serve as ligands for receptor guanylyl cyclase C (GC-C), and both receptor and ligands are expressed predominantly in the intestine. Ligand binding to GC-C results in increased cyclic GMP production in the cell which governs downstream signaling. In the last decade, a significant amount of research has unraveled novel functions for this class of peptide hormones, in addition to their action as intestinal secretagogues. An additional receptor for uroguanylin, receptor guanylyl cyclase D, has also been identified. Thus, unconventional roles of these peptides in regulating renal filtration, olfaction, reproduction, and cell proliferation have begun to be elucidated in detail. These varied effects suggest that these peptide hormones act in an autocrine, paracrine as well as endocrine manner to regulate diverse cellular processes.
Keywords: guanylin, uroguanylin, receptor guanylyl cyclase, GC-C, GC-D
Citation: Basu N and Visweswariah SS (2011) Defying the stereotype: non-canonical roles of the peptide hormones guanylin and uroguanylin. Front. Endocrin. 2:14. doi: 10.3389/fendo.2011.00014
Received: 24 April 2011;
Accepted: 26 May 2011;
Published online: 15 June 2011.
Copyright: © 2011 Basu and Visweswariah. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
*Correspondence: Sandhya Srikant Visweswariah, Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India. e-mail: firstname.lastname@example.org