Meta-analysis of functional magnetic resonance imaging studies on human auditory cortex.
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1
University of Helsinki, Finland
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2
Veterans Affairs Northern California Health Care System (VANCHSC), United States
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3
VANCHSC and University of California at Davis, United States
We meta-analyzed over 100 auditory functional magnetic resonance imaging (fMRI) studies reporting Talairach or MNI (Montreal Neurological Institute) coordinates of auditory-cortex (AC) activations related to processing of pitch, timbre, spatial location, speech, human voice or environmental sounds. A Matlab toolbox VAMCA (www.nitrc.org/projects/vamca/) was used to evaluate distributions of activations associated with different types of auditory processing in MNI space and in a two-dimensional cortical-surface space formed on the basis of anatomical data from 60 healthy adults. AC activations associated with spatial processing (e.g., sound localization or listening to moving vs. stationary sounds) had median loci in the posterior superior temporal gyrus (STG) in both hemispheres. Activations associated with processing of infrequent pitch changes had similar distributions. In contrast, activations for other types of pitch processing (e.g., pitch detection or listening to varying vs. fixed pitch) were located in the mid-STG. Permutation tests indicated that these activations were significantly anterior to those associated with infrequent pitch deviances or with spatial processing. Speech and voice processing, in turn, produced activations with similar median loci at the border of mid-STG and superior temporal sulcus. In the left hemisphere, these loci were significantly lateral/inferior to those related to processing of spectral features (i.e., pitch or timbre) in other kinds of sounds. Differences were also found between modulations of AC activity by attention to speech and attention-related modulations (ARMs) for non-speech sounds: In the left hemisphere, ARMs for speech had their median locus in the mid-STG and significantly anterior to that for non-speech sounds. Funding: Supported by the Academy of Finland (grants # 210587, 209709, 210186) and the Research Service of the United States Department of Veteran Affairs.
Keywords:
Auditory Cortex,
fMRI
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Symposium: Oral Presentation
Topic:
Symposium 5: Auditory processing
Citation:
Alho
K,
Rinne
T,
Herron
TJ and
Woods
DL
(2011). Meta-analysis of functional magnetic resonance imaging studies on human auditory cortex..
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00035
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Received:
09 Nov 2011;
Published Online:
15 Nov 2011.
*
Correspondence:
Prof. Kimmo Alho, University of Helsinki, Helsinki, Finland, kimmo.alho@helsinki.fi