Spectral power, phase-amplitude coupling and ultra-slow oscillations during rest in the human posteromedial cortex
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1
Stanford University, United States
Posteromedial cortex (PMC) includes the cortices of the posterior cingulate, retrosplenial and precuneus, and is the core region of the default-mode network (DMN), which is known for its high metabolic activity during the resting state. Despite a large number of neuroimaging studies of this region, little is known about the electrophysiological properties of the PMC during the resting state. Using intracranial recordings in 6 patients, we quantified PMC spectral power, phase-amplitude coupling and slow oscillation at rest. Spectral estimations were calculated with standard Fourier methods and phase-amplitude coupling (PAC) calculated using phase locking estimation of Hilbert transformed narrow band frequencies. Recordings from the PMC were dominated by delta and theta band spectral peaks (~2-6Hz), which subsequently defined the phase preference of amplitude modulation in the gamma range (40 – 200Hz). This PAC preference was clearly distinguished from local visual (alpha) and distal motor (beta) sites. Using these PAC preferences spectra of nested slow oscillations showed peaks in the 0.01-0.16Hz range. Human intracranial recordings show a clear link between the local resting peak spectral frequency and preferred phase frequency of cross-frequency coupling, which consequently differs across nodes in putative resting state brain networks. PMC in particular appears to be highly modulated by local delta and theta oscillations. Furthermore this oscillatory preference may also help to identify domains in cross-frequency space that modulate at slow time scales more akin to those observed with hemodynamic neuroimaging. Funding: This work is supported by the Stanford University BioX program.
Keywords:
Intra-cranial Electrophysiology,
PMC,
Ultra-slow oscillations
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Foster
BL,
Dastjerdi
M and
Parvizi
J
(2011). Spectral power, phase-amplitude coupling and ultra-slow oscillations during rest in the human posteromedial cortex.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00068
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Received:
16 Nov 2011;
Published Online:
25 Nov 2011.