Emotional impairment induced by deep brain stimulation of subthalamic nuclei in parkinson’s disease
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1
Université Blaise Pascal, France
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2
Université de Rennes, France
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3
Université de Savoie, France
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4
Université Catholique de Louvain, Belgium
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5
Universitary Hospital Center of Clermont-Ferrand, France
Deep brain stimulation of subthalamic nuclei (STN-DBS) is an efficient technique to remediate motor symptoms in Parkinson’s disease. However, different studies have shown that DBS may induce not only cognitive or addictive disorders but also emotional disorders. We hypothesized the motor disorders characterizing Parkinson’s disease will induce significant impairment of different emotional expressions but also that STN-DBS and L-Dopa might produce a specific impairment for emotions related to subcortical structures, particularly for low spatial frequency information (Vuilleumier et al., 2003). The aim of this study was to evaluate the effect of deep brain stimulation on impairments of emotional facial expressions at different spatial frequencies. We conducted an emotional facial recognition task, at different spatial frequencies, with suboptimal (200 ms) presentation of the stimuli. 15 patients were assessed on their ability to recognize emotional facial expressions depicting the seven basic emotions (anger, disgust, fear, happiness, neutral, sadness, and surprise) at 3 spatial frequency channels (low spatial frequency, high spatial frequency and normal images). The recognition task was applied with and without deep brain stimulation of subthalamic nuclei and with or without L-Dopa medication. Patients were compared to 15 matched healthy control participants. Fast presentation of the stimuli revealed that Parkinson’s disease patients exhibit a global impairment for different facial expressions but also that STN-DBS and L-Dopa yield a significant interaction effect on the ability to recognize emotional expressions by Parkinson’s disease patient at different spatial frequencies.
Keywords:
Neuropsychiatry,
STN-DBS
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Neuropsychiatric Applications
Citation:
Mermillod
M,
Musca
SC,
Mondillon
L,
Devaux
D,
Chambres
P,
Auxiette
C,
Vermeulen
N,
Jalenques
I and
Durif
F
(2011). Emotional impairment induced by deep brain stimulation of subthalamic nuclei in parkinson’s disease.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00117
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Received:
17 Nov 2011;
Published Online:
25 Nov 2011.
*
Correspondence:
Prof. Martial Mermillod, Université Blaise Pascal, Clermont-Ferrand, France, Martial.Mermillod@upmf-grenoble.fr