Investigating the neural correlates of metamemory using functional magnetic resonance imaging (fMRI) and intracranial electroencephalography (IEEG)
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1
Epileptology University Bonn, Germany
Memory performance in everyday life is often far from perfect. Thus, people usually monitor and control the learning progress by metamemory evaluations, such as judgments of learning (JOLs). We first investigated the neural correlates of JOLs using fMRI in 17 healthy subjects with a face – name paired associates design. In general, we found that actual memory success was associated with increased brain activation of bilateral hippocampi but dissociated from predicted memory which was correlated with larger brain activation of a prefrontal network. Since we found that the hippocampus was recruited during the JOL phase, we conducted an iEEG study in 11 presurgical epilepsy patients with hippocampal and rhinal depth electrodes. Patients were presented with unfamiliar faces and had to provide JOLs. In the subsequent retrieval phase, faces were shown again intermixed with 50 % new faces for a recognition memory test. Analyses of event-related potentials (ERP) of remembered versus forgotten trials yielded increases of the rhinal N400 component, as well as of late positive hippocampal ERP components. The memory predictions revealed only significant differences of hippocampal ERPs. However, accurate memory predictions were correlated with effects in the rhinal cortex in an early and late time phase, and with a late ERP effect in the hippocampus. Our data demonstrate that memory predictions per se rely on hippocampal activation, whereas accurate predictions might require an interaction of neocortical areas mediating monitoring/ control of incoming information, and the hippocampus. We suggest that this interaction is reflected by early and late rhinal ERP effects. The latter effects were not observed during memory encoding indicating that JOLs do not reduce to encoding processes.
Keywords:
cognitive control,
ERP
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Performance Monitoring and Cognitive Control
Citation:
Do Lam
AT,
Axmacher
N,
Elger
CE and
Fell
J
(2011). Investigating the neural correlates of metamemory using functional magnetic resonance imaging (fMRI) and intracranial electroencephalography (IEEG).
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00245
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Received:
21 Nov 2011;
Published Online:
28 Nov 2011.
*
Correspondence:
Dr. Anne T Do Lam, Epileptology University Bonn, Bonn, Germany, anne.dolam@ukb.uni-bonn.de