A voxel-based morphometry study of semantic deficits in alzheimer’s disease and mild cognitive impairment patients
-
1
Universitat de Barcelona, Spain
-
2
Universidad de Oviedo, Spain
-
3
Hospital de Cabueñes, Spain
-
4
University of Hull, United Kingdom
-
5
San Camillo Hospital (IRCCS), Italy
The aim of this study was to determine the brain areas responsible for the semantic impairment observed in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) patients. Thirteen 13 AD, 14 MCI patients, and 13 matched healthy seniors were assessed with a test battery aimed to study their semantic competence. Different subtasks were designed to study their semantic knowledge related to objects and faces in the context of semantic retrieval- and semantic association-dependent tasks. Aggregate scores obtained in the different tests were entered into voxel-based regression analyses with grey matter volume values obtained from three-dimensional brain MRI scans. Areas of significant correlation between volume loss and poor semantic scores were restricted to the temporal lobe in the AD group, while in the MCI and control groups significant associations were found with lower grey matter volume values in a network of bilateral fronto-temporo-parietal regions. Our results suggest that degradation of partially overlapping and widely distributed neural networks, mainly including temporal regions, subserve semantic deficits related to objects and faces in AD and MCI patients.
Keywords:
AD,
Aging,
MCI
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Cognitive Aging
Citation:
Rodríguez-Ferreiro
J,
Cuetos
F,
Monsalve
A,
Martínez
C,
Pérez
A and
Venneri
A
(2011). A voxel-based morphometry study of semantic deficits in alzheimer’s disease and mild cognitive impairment patients.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00546
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
15 Nov 2011;
Published Online:
28 Nov 2011.
*
Correspondence:
Dr. Javier Rodríguez-Ferreiro, Universitat de Barcelona, Barcelona, Spain, xabelferreiro@gmail.com