NEURAL CORRELATES OF EMOTIONAL PROCESSING IN PARKINSON’S DISEASE AND THE INFLUENCE OF AFFECTIVE DISTURBANCES
Nadeeka
Dissanayaka1, 2*,
Tiffany
Au2,
Anthony
Angwin3,
David
Copland2, 3,
John
O'Sullivan1, 2,
Gerard
Byrne4,
Rodney
Marsh5,
George
Mellick1, 6 and
Peter
Silburn1, 2
-
1
Royal Brisbane & Women's Hospital, Neurology, Australia
-
2
University of Queensland, UQ Centre for Clinical Research, Australia
-
3
University of Queensland, School of Health & Rehabilition Sciences, Australia
-
4
University of Queensland, School of Medicine, Australia
-
5
Royal Brisbane & Women's Hospital, Psychiatry, Australia
-
6
Griffith University, Eskitis Institute for Cell & Molecular Therapies, Australia
BACKGROUND: Reduced ability to discriminate emotions has been reported in patients with Parkinson’s disease (PD). We aimed to pinpoint neural correlates of emotional processing and the influence of affective disturbances in emotional judgement in PD patients.
METHODS: Thirty (30) PD patients performed a word affective priming task while ERPs were recorded. Hamilton depression and anxiety rating scales were administered. In order to elicit ERP correlates of automatic emotional judgement, the task presented negative or neutrally valanced two words consecutively at a 150ms interval. Participants evaluated the valance of the second word (target word) and ERPs generated when responding to target words were recorded. Repeated measures ANOVA 2X2 models for 300-500ms and 600-800ms time windows were constructed for the midline brain regions, and depression or anxiety ratings were added as covariates. Difference waves were calculated for congruency or target valence effects, and partial correlations between the difference wave, and depression and anxiety ratings were computed.
RESULTS: Overall target valence effects were observed for Pz and POz channels, while depression and anxiety scores influenced these results. An enhanced late positive potential (LPP; 600-800ms) was observed for Pz when evaluating congruent neutral compared to negative words for PD patients with high anxiety, independent of depression (FPz=8.63; p=0.007; r=0.47; p=0.01).
CONCLUSION: Results showed attentional biases in emotional processing of PD patients. In contrast to PD patients without anxiety, anxious PD patients illustrated opposite effects at the parietal region, and suggested a requirement of additional attentional resources to distinguish neutral in comparison to negative words.
Acknowledgements
We would like to acknowledge funding bodies: Royal Brisbane & Women's Hospital Foundation, Parkinson's Queensland Inc and Lions Medical Research Foundation, research assistants: Alicia Rawlings and Hanna Reinebrant, and all participants of the study.
Keywords:
event related potentials (ERP),
Affective Priming,
Affective Disorders,
Parkinson Disease,
Depression,
Anxiety,
late positive potential,
visual words,
emotional processing
Conference:
ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia, 29 Nov - 2 Dec, 2012.
Presentation Type:
Oral Presentation
Topic:
Emotion and Social
Citation:
Dissanayaka
N,
Au
T,
Angwin
A,
Copland
D,
O'Sullivan
J,
Byrne
G,
Marsh
R,
Mellick
G and
Silburn
P
(2012). NEURAL CORRELATES OF EMOTIONAL PROCESSING IN PARKINSON’S DISEASE AND THE INFLUENCE OF AFFECTIVE DISTURBANCES.
Conference Abstract:
ACNS-2012 Australasian Cognitive Neuroscience Conference.
doi: 10.3389/conf.fnhum.2012.208.00140
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Received:
25 Oct 2012;
Published Online:
17 Nov 2012.
*
Correspondence:
Dr. Nadeeka Dissanayaka, Royal Brisbane & Women's Hospital, Neurology, Brisbane, Australia, n.dissanayaka@uq.edu.au