Right-hemispheric Dominance Of Dentate Granule Cell Activity After Spatial Exploration In Split-brain Mice But Not In Acallosal Mutant Mice
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1
Faculty of veterinary Medicine, South Valley University, Physiology Department, Egypt
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2
Research institute for electronic science, Hokkaido University, Laboratory of molecular and cellular biophysics, Japan
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3
Nagoya University, Department of anatomy and molecular cell biology, Japan
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4
National Institute for Physiological Sciences, Division of Cerebral Structure, Japan
In the last decade, left/right brain asymmetry studies have been focused on the molecular level of the hippocampus. First, left/right asymmetry has been reported in GluN2B-NMDA subunit distribution and synaptic plasticity in hippocampal pyramidal cell synapses depending on the side of input (Kawakami et al, 2003). Furthermore, Shinohara et al (2008) found that GluA1-AMPA receptor subunit density, PSD size and spine head volume are larger in CA1 radiatum synapses contacting with presynaptic fibers from right than left CA3. Second, right isomerism in terms of the GluN2B asymmetry was found in inversus viscerum (iv) mice (Kawakami et al, 2008). Third, right-side dominance in spatial learning was reported in split-brain mouse (Shinohara et al, 2012). In the present study, we investigated asymmetry of hippocampal neural activity in wild-type, iv, Arc-Venus transgenic and acallosal mutant mice. Arc-Venus mice have the ability to produce destabilized form of Venus (derivative of green fluorescent protein) controlled by Arc-promoter which is activated by neural stimulation. These mice received transection of ventral hippocampal commissure and corpus callosum with unilateral eye deprivation to force each mice use predominantly either left or right hippocampus during spatial learning. Both left and right eye deprived wild-type mice showed right-side dominance of c-Fos expression in dentate gyrus with a similar tendency in CA1. Venus expression and Venus-immunopositive cells in left eye deprived Arc-Venus mice also showed right-side dominance confirming the dominance of neural activity in right hippocampus. Interestingly, c-Fos positive cells in left eye deprived iv mice also showed right-side dominance regardless of normal or inverted asymmetry in internal organs. On the other hand, left and right eye deprived acallosal mutant mice showed lack of left/right asymmetry in neural activity. These results suggest right-hemispheric dominance in spatial learning in mice and a critical role of corpus callosum for the development of this asymmetry.
Keywords:
split-brain,
asymmetry,
Dentate Gyrus,
Right-dominance,
Acallosal mice
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Ahmed
H,
KAWAKAMI
R,
FUKAZAWA
Y and
Shigemoto
R
(2013). Right-hemispheric Dominance Of Dentate Granule Cell Activity After Spatial Exploration In Split-brain Mice But Not In Acallosal Mutant Mice.
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00003
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Received:
06 Feb 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Dr. Hassan Ahmed, Faculty of veterinary Medicine, South Valley University, Physiology Department, Qena, 83523, Egypt, hassan-Younes@vet.svu.edu.eg