Vasopressin depresses long term potentiation in the mouse hippocampus.
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1
Centre National de la Recherche Scientifique, France
Vasopressin, besides its well known endocrine actions, is now recognized as a neurotransmitter in the brain, implicated in the regulation of social and affective behavior. Several recent findings indicate an involvement of the V1a and V1b vasopressin receptors in stress and depression and point out the limbic system as a putative target. The V1a receptor has a wide distribution but the V1b receptor displays a particularly high expression in the CA2 pyramidal area of the hippocampus. Accordingly, we have focused on this region to determine the effect of vasopressin on synaptic activity.
Either whole-cell recording from the soma of pyramidal CA2 neurons or field recording along their dendrites in acute slices from C57Bl6 mice were performed. The synaptic activity in response to stimulation of the LIII entorhinal cortex (EC) afferents was measured. High frequency stimulation (HFS) induced a long term potentiation (LTP) of the excitatory post synaptic potential (EPSP) in the majority of pyramidal cells.
Bath application of vasopressin (1 min., 10-100 nM) transiently decreased the LTP-enhanced EPSP by 15%. Of interest is the fact that the vasopressin-induced EPSP reduction was observed only after LTP establishment. In addition, vasopressin had no effect on the EPSP recorded in CA1 pyramidal cells in response to stimulation of the Schaffer collaterals, even after establishment of a stable LTP.
Our data indicate that vasopressin, by decreasing specifically a synaptic input on CA2 pyramidal cells after LTP, can modulate the recently described (Chevaleyre and Siegelbaum, Neuron, 2010) disynaptic pathway involving EC afferents, the CA2 pyramidal cells and their target CA1 neurons. The identity of the vasopressin receptors implicated in this response, and the cognitive consequences of this inhibition, will be the matter of our future studies.
Acknowledgements
C.M. supported by ANR.
Keywords:
vasopressin,
LTP,
Stress, Physiological,
CA2 Region, Hippocampal,
Memory
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Symposium
Topic:
Abstracts
Citation:
Chafai
M,
Guillon
G and
Desarmenien
MG
(2013). Vasopressin depresses long term potentiation in the mouse hippocampus..
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00014
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Received:
29 Jan 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Dr. Michel G Desarmenien, Centre National de la Recherche Scientifique, Montpellier, France, mdesarmenien@igf.cnrs.fr