Maturation of Mismatch Negativity – implications for Ultra High risk schizophrenia research
Renate
Thienel1, 2, 3*,
Ross
W.
Fulham1,
Benjamin
Weissmueller4,
Nicole
Kilberg-Hanzon5,
Helen
Stain6,
Bethany
Patch7,
Juanita
Todd1, 2, 3, 8 and
Ulrich
Schall1, 2, 3
-
1
University of Newcastle, Priority Centre for Translational Neuroscience & Mental Health Research, Australia
-
2
Schizophrenia Research institute, Australia
-
3
Hunter Medical Research institute, Australia
-
4
University of Bremen, Germany
-
5
Karolinska Institute, Sweden
-
6
University of Durham, United Kingdom
-
7
Royal Melbourne Institute of Technology, Australia
-
8
School of Psychology, University of Newcastle, Australia
Background: Mismatch negativity (MMN) is an event related potential (ERP) component, usually obtained by presenting a train of identical stimuli (Standard) interspersed with a physically deviant stimulus. High-risk research uses MMN, to predict transition to psychosis. However, reference data on normal MMN-development is sparse and depends on the methodology. Method: We collected developmental data in a large healthy cohort (N=67) of volunteers between 6-25 years across 4 age-groups (1) 6-10 yrs, N=14;(2) 11-15 yrs , N=13; (3) 16-20 yrs, N= 20; (4) 21-25 yrs, N=20. We used standard MMN (duration, frequency, intensity). and a separate phonetic MMN paradigm [(monaural, right ear task [92% standards (/da/, 20ms voice onset time (VOT)); 8% deviants (/ga/, 60ms VOT)]. We furthermore tested the participants with a neuropsychological battery, across attention, memory and language domains. Analysis of variance was performed across age groups with deviant type (duration, frequency, intensity) and electrode site (left, midline, right) as repeated measures, and frontal, central, parietal electrode groups as separate within subject measures. The phonetic deviant data was separately analysed in a similar GLM. Correlations with neuropsychological data were performed. Results: Age and deviant-type interacted, with significant increase of MMN amplitudes to duration- and phoneme-deviants with increase of age. Neuropsychological variables correlated with MMN. Conclusions: The establishment of a developmental database of MMN is crucial as a reference for high-risk populations. MMNs to duration and phonetic deviants might be influenced notably by neurodevelopment.
Keywords:
MMN,
phonemes,
development,
mismatch negativity (MMN),
Cognition
Conference:
ACNS-2013 Australasian Cognitive Neuroscience Society Conference, Clayton, Melbourne, Australia, 28 Nov - 1 Dec, 2013.
Presentation Type:
Poster
Topic:
Sensation and Perception
Citation:
Thienel
R,
Fulham
RW,
Weissmueller
B,
Kilberg-Hanzon
N,
Stain
H,
Patch
B,
Todd
J and
Schall
U
(2013). Maturation of Mismatch Negativity – implications for Ultra High risk schizophrenia research.
Conference Abstract:
ACNS-2013 Australasian Cognitive Neuroscience Society Conference.
doi: 10.3389/conf.fnhum.2013.212.00089
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Received:
25 Sep 2013;
Published Online:
25 Nov 2013.
*
Correspondence:
Dr. Renate Thienel, University of Newcastle, Priority Centre for Translational Neuroscience & Mental Health Research, Newcastle, Australia, renate.thienel@newcastle.edu.au