KIBRA rs17070145 polymorphism and resting EEG spectral activity: Biomarkers for reduced risk of Alzheimer’s disease
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1
Western Sydney University, National Institute of Complementary Medicine, Australia
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2
University of Wollongong, Centre for Psychophysics, Psychophysiology, and Psychopharmacology, Australia
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3
University of Wollongong, Illawarra Health and Medical Research Institute, Australia
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4
Schizophrenia Research Institute, Australia
KIBRA (KIdney/BRAin) is a cytoplasmic protein encoded by the WWC1/KIBRA gene and is primarily expressed in memory-related regions of the brain (hippocampus, cortex). A functional Single Nucleotide Polymorphism (SNP) (rs17070145) within KIBRA has been associated with memory performance and Alzheimer’s disease risk. Recent work has demonstrated that KIBRA T allele carriers have significantly better episodic memory scores than non-carriers, and a reduced risk of Alzheimer’s disease. Identifying EEG biomarkers of KIBRA T allele carrier status may further our understanding of the impact of this SNP on neural networks, and early risk factors for Alzheimer’s disease. Sixty-one young adults had their resting EEG activity continuously recorded from 30 scalp sites for 2 minutes with their eyes open. Participants also completed a computerised neurocognitive test battery (CogState), and provided a saliva sample for DNA extraction and analysis. Mean EEG band power was computed across the 2-minute block for delta, theta, alpha, beta, and gamma. The genotyping for KIBRA rs17070145 polymorphism was performed using Sequenom MassARRAY® genotyping assay. KIBRA T allele carrier status was compared with EEG activity and CogState scores. Delta, theta, alpha, beta, and gamma bands showed the expected eyes-open resting state topographic distributions. KIBRA T allele carrier status was related to delta and theta only, with greater delta power at the vertex and midline parietal sites, and reduced theta power centrally on the left for T allele carriers. Increased delta levels also improved reaction time in a sustained attention task independent of KIBRA T allele carrier status. Results indicate that delta and theta power are modulated by KIBRA. Given the role of the hippocampal-cortical memory system in the generation of slow wave activity, further work should explore whether KIBRA affects this neural network during cognitive tasks, and whether this activity is associated with Alzheimer’s disease risk.
Keywords:
Electroencephalography,
Delta Rhythm,
Theta Rhythm,
KIBRA,
single nucleotide polymorphism (SNP),
Alzheimer's disease,
Memory
Conference:
ASP2015 - 25th Annual Conference of the Australasian Society for Psychophysiology, Sydney, Australia, 2 Dec - 4 Dec, 2015.
Presentation Type:
Oral Presentation
Topic:
Psychophysiology
Citation:
Steiner
GZ,
Fernandez-Enright
F,
Barry
RJ and
Barkus
E
(2015). KIBRA rs17070145 polymorphism and resting EEG spectral activity: Biomarkers for reduced risk of Alzheimer’s disease.
Conference Abstract:
ASP2015 - 25th Annual Conference of the Australasian Society for Psychophysiology.
doi: 10.3389/conf.fnhum.2015.219.00039
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Received:
26 Oct 2015;
Published Online:
30 Nov 2015.
*
Correspondence:
Dr. Genevieve Z Steiner, Western Sydney University, National Institute of Complementary Medicine, Penrith, NSW, 2751, Australia, G.Steiner@westernsydney.edu.au