Poperties of the Intrinsic and Extrinsic Uni- and Bilateral Connectome of the Spinal Cord of the Rat
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1
University of Rostock, Anatomy, Germany
The spinal cord (SC) of the rat consists of 34 segments from the cervical to the coccygeal level which contain 10 principal layers (Rexed I-X) on the left and the right side surrounded by white matter. Here, efferents to and afferents from peripheral organs as well as intrinsic connections (C) of SC have been investigated in about 800 peer-reviewed tract tracing publications. The connectivity data of these publications have been transfered into the rat connectome dataset in neuroVIISAS (Schmitt and Eipert 2012, Schmitt and et al. 2012). SC regions were organized in a hierarchy to allow multiresolution analysis (Fig. 1).
In the intrinsic bilateral connectome of the SC (891 regions) 26222 C were documented at the level of layers (ipsi: 11297, contra: 805). 5213 C are reciprocal which appears to be significant because in Erdös-Rényi (ER) simulations an average of 437.1 reciprocal connections was found. The small-worldness coefficient (SWC) is 3.598 (ER: 1). Furthermore, the
connections of the network have a scale-free distribution. Local connectivity analysis revealed that cervical, thoracic and lumbal layers II-VIII possess most intrinsic connections. The layers III-IX of thoracal segment 3 have the largest eigenvector centrality of 0.709 as well as the largest Katz-index. The extrinsic contralateral (146 regions, C=7405) and ipsilateral connectome (171 regions, C=4178) have been analyzed at the level of segments. In contrast to the intrinsic connectome the SWS increases to 5.207 in the ipsilateral and decrese to 2.19 in the contralateral extrinsic SC connectome. In conclusion, we build the first bilateral connectome of the SC of a mamalian for which the most detailed tract tracing investigations exist and integrated it into the complete rat nervous system connectome.
Figure 1: The regions at the level of segments of the left and right side of the SC are arranged symmetrically. Connections are directed and colors of connections indicate the density of connections, respectively, the weights. CS: cervical, T: thoracic, L: lumbal, Sa: sacral.
References
Schmitt O, Eipert P (2012) Neuroinformatics 10:243-267.
Schmitt O, Eipert P, Philipp K, Kettlitz R, Fuellen G, Wree A (2012) Front Neural Circuits 6:81.
Keywords:
connectome,
Spinal Cord,
rat,
Modeling and simulations,
visualization
Conference:
Neuroinformatics 2013, Stockholm, Sweden, 27 Aug - 29 Aug, 2013.
Presentation Type:
Poster
Topic:
General neuroinformatics
Citation:
Schmitt
O,
Eipert
P,
Klünker
A,
Kettlitz
R,
Morawska
P,
Meinhardt
J and
Wree
A
(2013). Poperties of the Intrinsic and Extrinsic Uni- and Bilateral Connectome of the Spinal Cord of the Rat.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2013.
doi: 10.3389/conf.fninf.2013.09.00080
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Received:
04 Mar 2013;
Published Online:
11 Jul 2013.
*
Correspondence:
Prof. Oliver Schmitt, University of Rostock, Anatomy, Rostock, 18057, Germany, schmitt@med.uni-rostock.de