Mapping the marmoset monkey cortex and the construction of a multimodal digital atlas
Tristan
A.
Chaplin1*,
Hsin-Hao
Yu1,
Piotr
Majka2,
Cecil
C.
Yen3,
Sofia
Bakola1,
Jakub
M.
Kowalski2,
Chia-Chun
Hung3,
Kathleen
J.
Burman1,
Daniel
K.
Wójcik2,
Afonso
C.
Silva3 and
Marcello
G.
Rosa1, 4
-
1
Monash University, Department of Physiology, Australia
-
2
Nencki Institute of Experimental Biology, Poland
-
3
National Institutes of Health, National Institute of Neurological Disorders and Stroke, United States
-
4
Monash Vision Group, Australia
Mapping the cerebral cortex is a critical step in understanding the function of the human brain. Non-human primates can provide us with detailed information to help us understand the general organization principles of the cerebral cortex. We have been mapping the cortex of the marmoset monkey, a promising primate animal model, using a variety of techniques and are in the process of consolidating the data into a standardized digital atlas. In the atlas, the cortex has been subdivided into 115 cytoarchitecturally defined areas and we have constructed both surface and volumetric based representations. We have extensive retinotopic maps of the primary visual cortex from microelectrode recordings which have been incorporated into the atlas. We have also registered connection data from tracer injections in the prefrontal and motor cortex as part of work to build a connectivity atlas. Recently, we have incorporated MRI myelin maps into the atlas and are working towards adding cortical thickness and fMRI data. Finally, we have registered the marmoset atlas to atlases of macaques and humans. This has allowed us to identify differences between species, in particular, regions of the cortex that are disproportionately large in larger primate species. The interspecies registration also allows for the mapping of data from one species to another for comparative analysis or registration refinement.
Keywords:
marmoset,
Cerebral Cortex,
evolution,
MRI,
connectome,
cortical mapping,
atlasing
Conference:
Neuroinformatics 2013, Stockholm, Sweden, 27 Aug - 29 Aug, 2013.
Presentation Type:
Poster
Topic:
Digital atlasing
Citation:
Chaplin
TA,
Yu
H,
Majka
P,
Yen
CC,
Bakola
S,
Kowalski
JM,
Hung
C,
Burman
KJ,
Wójcik
DK,
Silva
AC and
Rosa
MG
(2013). Mapping the marmoset monkey cortex and the construction of a multimodal digital atlas.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2013.
doi: 10.3389/conf.fninf.2013.09.00122
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Received:
16 Aug 2013;
Published Online:
27 Nov 2013.
*
Correspondence:
Mr. Tristan A Chaplin, Monash University, Department of Physiology, Melbourne, VIC, 3800, Australia, tristan.chaplin@monash.edu