A Wiring Diagram of Protocerebral Bridge for Visual Information Processing in the Drosophila Brain
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1
Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Taiwan
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2
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Taiwan
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3
National Center for High-performance Computing, Taiwan
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4
Brain Research Center, National Tsing Hua University, Taiwan
A major challenge in neuroscience is to understand how a physical wiring network relays information flow from sensory input to behavioral output in a complex brain. The protocerebral bridge (PB) is a major part of the insect central complex, a pre-motor center analogous to the human basal ganglia. By deconstructing the adult Drosophila PB network into hundreds of single neurons and reconstructing them into a common 3D framework, we have constructed a comprehensive map of PB circuits with labeled polarity and predicted directions of information flow. Our analysis reveals a highly ordered information processing system that involves directed information flow among CX subunits through 194 distinct PB neuron types. This system follows several highly-ordered wiring principles indicating multiple levels of mirror, convergence, divergence, reverberation and parallel signal propagation within the CX. This layout of PB neuronal circuitry provides some clues as to how visual sensory cues are processed in the fly’s brain to drive proper locomotor output.
Keywords:
protocerebral bridge,
visual information processing,
Drosophila brain,
wiring diagram,
Neuron types
Conference:
Neuroinformatics 2014, Leiden, Netherlands, 25 Aug - 27 Aug, 2014.
Presentation Type:
Poster, not to be considered for oral presentation
Topic:
General neuroinformatics
Citation:
Lin
C,
Chuang
C and
Chiang
A
(2014). A Wiring Diagram of Protocerebral Bridge for Visual Information Processing in the Drosophila Brain.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2014.
doi: 10.3389/conf.fninf.2014.18.00004
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Received:
02 Apr 2014;
Published Online:
04 Jun 2014.
*
Correspondence:
Prof. Ann-Shyn Chiang, Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Taipei, Taiwan, c00cjz00@narlabs.org.tw