Alterations in goal-directed behavior but not emotion after lesions of distinct subregions of macaque orbital prefrontal cortex
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1
National Institute of Mental Health, Laboratory of Neuropsychology, United States
Damage to the orbital prefrontal cortex (PFo) results in marked changes in goal-directed behavior and affect. Two distinct subregions have been identified within the PFo: 1) the central part of Pfo, areas 11 and 13, and 2) the medial part of PFo, area 14. Although it has been proposed that the functions of the subregions may differ, evidence is limited. To test this possibility we compared rhesus monkeys (Macaca mulatta) with excitotoxic lesions of either areas 11/13 (n=4) or area 14 (n=4) with a group of unoperated controls (n=4). The extent of the lesions was confirmed by T2-weighted MRI. We used two tasks: reinforcer devaluation and extinction of responses to a previously rewarded object. We also evaluated emotional responses to a rubber snake. Monkeys with lesions of area 11/13 were impaired on reinforcer devaluation but not extinction. Monkeys with lesions of area 14 showed the converse result, namely, impairment in extinction but not reinforcer devaluation. All three groups behaved similarly in response the the rubber snake. These preliminary results, which show selective changes in goal directed behavior in the absence of changes in emotion, are in contrast with previous reports of macaques with more extensive PFo lesions.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Murray
EA and
Rudebeck
PH
(2010). Alterations in goal-directed behavior but not emotion after lesions of distinct subregions of macaque orbital prefrontal cortex.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00088
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Received:
29 Jun 2010;
Published Online:
29 Jun 2010.
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Correspondence:
E. A Murray, National Institute of Mental Health, Laboratory of Neuropsychology, Bethesda, United States, murraye@mail.nih.gov