Use of MRI cortical thickness, FDG PET, and PIB (Pittsburgh B) PET imaging to distinguish atypical Alzheimer's Disease and frontotemporal dementia cases
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1
McGill University Montréal, Bloomfield Centre for Research in Aging, Lady Davis Institute, Canada
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2
McGill University, Department of Clinical Neurosciences, Jewish General Hospital, Canada
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3
McGill University, McConnel Brain Imaging Centre, Montreal Neurological Institute, Canada
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4
Université de Montréal, Service de neurologie, CHUM, Canada
Background: Many cases of progressive dementia are not clinically typical for Alzheimer’s Disease. Fronto-temporal dementia (FTD) or variants are often considered, but are by no means certain clinical diagnoses. More precise diagnosis is needed. Methods: 35 patients were studied; 12 meeting criteria for “probable AD”, and 6 judged to be FTD or one of its variants with “high probability”. The other 17 were judged to be “atypical / possible AD/ possibly FTD, and the degree of diagnostic certainly was rated as medium to low. All were studied with thin cut MRI imaging (with regional cortical thickness, hippocampal volumetrics, and VBM analyses), FDG PET, and PET amyloid imaging with PIB (Pittsburgh B Compound). Results: Of those 12 subjects meeting criteria for “probable AD”, 11 remained classified as such after multi-modal imaging, but one was reclassified as FTD. Of the 6 patients judged to be FTD with “high certainty”, four remained as such, while two were reclassified as AD. Of the 17 rated clinically with medium to low diagnostic certainty, all were reclassified – 15 as AD, and 2 as FTD.
Conclusions: Multi-modal imaging was successful in classifying all medium and low certainty cases in a convergent manner.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neurologic
Citation:
Chertkow
H,
Evans
A,
Leger
G,
Litwin
L,
Nikelski
J and
Whitehead
V
(2010). Use of MRI cortical thickness, FDG PET, and PIB (Pittsburgh B) PET imaging to distinguish atypical Alzheimer's Disease and frontotemporal dementia cases.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00140
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Received:
01 Jul 2010;
Published Online:
01 Jul 2010.
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Correspondence:
H. Chertkow, McGill University Montréal, Bloomfield Centre for Research in Aging, Lady Davis Institute, Montréal, Canada, Howard.chertkow@mcgill.ca