Auditory Novelty Processing in Patients with Orbitofrontal or Lateral Prefrontal Lesions - An Event-Related Potential (ERP) Study
-
1
Oslo University Hospital – Rikshospitalet, Department of Radiology, Sweden
-
2
University of Oslo, Department of Psychology, Norway
-
3
Oslo University Hospital – Rikshospitalet, Department of Neuropsychiatry and Psychosomatic Medicine, Norway
-
4
University of California, Helen Wills Neuroscience Institute, United States
-
5
University of Lund, Department of Psychology, Sweden
-
6
Sunnaas Rehabilitation Hospital, Norway
-
7
Oslo University Hospital – Rikshospitalet, Department of Neurosurgery, Norway
Attentional resource allocation to novel events is reflected in the novelty P3 ERP-component. Patients with orbitofrontal (OFC) or lateral prefrontal (LPFC) lesions were assessed with an auditory novelty P3 oddball paradigm. Methods Thirteen patients with OFC and 6 with LPFC lesions participated along with 15 healthy controls. EEG was recorded using a 128-channel EGI-system. The task consisted of 280 standard tones (1000Hz), 60 targets (1500Hz) requiring a button press, and 60 task-irrelevant novel environmental sounds. Results Both patients and controls demonstrated high hit-rates to targets (>92%) and few false alarms to novels (<2%). The groups did not differ in the parietal P3b-response to targets. Both patient groups had attenuated novelty P3s, with the LPFC group showing an additional sustained negative slow wave predominantly over lesioned cortex. The negativity was present to targets and novels, but had shorter duration for targets. Conclusions Novelty processing was affected differentially dependent on lesion site. The OFC and LPFC groups both showed novelty P3 attenuation, while LPFC lesions were associated with an increased late negativity to novels. The results indicate that lateral and orbital regions of the PFC are involved in novelty processing, but that LPFC damage results in abnormal sustained processing of novel events.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neuropsychology
Citation:
Due-Tønnessen
P,
Endestad
T,
Funderud
I,
Knight
R,
Lindgren
M,
Løvstad
M,
Meling
T,
Solbakk
A and
Voytek
B
(2010). Auditory Novelty Processing in Patients with Orbitofrontal or Lateral Prefrontal Lesions - An Event-Related Potential (ERP) Study.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00167
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
01 Jul 2010;
Published Online:
01 Jul 2010.
*
Correspondence:
M. Løvstad, Sunnaas Rehabilitation Hospital, Nesodden, Norway, Mar.lovstad@gmail.com