The role of rostral prefrontal cortex – area 10 –in maintaining and monitoring higher order task goals
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1
MRC Cognition & Brain Sciences Unit, United Kingdom
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2
Institute of Cognitive Neurology (INECO), Argentina
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3
Favaloro University, Institute of Neuroscience, Argentina
Rostral prefrontal cortex -BA10 -is supposed to play a role in cognitive control by the selection and maintenance of higher order internal goals while other sub-goals are being performed. While most of the data to support this view come from functional neuroimaging studies, lesion studies providing evidence in favor of this view are scant. We compared a group of frontal patients whose lesions involved BA10, a group of frontal patients whose lesions did not affect this area, and normal controls on the Hotel Task, which was designed to measure the ability to maintain higher order goals while performing other sub-goals needed to complete task performance. We also searched for correlations between task performance and volume of damage within different sub-regions of BA10. Only the group with lesions involving BA10 showed deficits on the Hotel Task. Significant correlations were found between Hotel Task performance and volume of damage in lateral right BA10, with no similar correlation for left lateral, left medial or right medial damage. Anterior prefrontal cortex lesions produce deficits in tasks that involve higher order goals while performing other sub-goals.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neuropsychology
Citation:
Duncan
J,
Gleichgerrcht
E,
Manes
F,
Roca
M,
Thompson
R and
Torralva
T
(2010). The role of rostral prefrontal cortex – area 10 –in maintaining and monitoring higher order task goals.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00169
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Received:
01 Jul 2010;
Published Online:
01 Jul 2010.
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Correspondence:
F. Manes, Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina, fmanes@neurologiacognitiva.org