Funding: The authors would like to thank German Research Foundation (DFG-CRC-SFB-1047 to ZA and DFG-CRC-TR34/Z1 to SZ, TD) for funding on this research.
Support: The authors thank to the University of Wuerzburg Germany, University of Massachusetts USA and The Jackson Laboratory for Genomic Medicine USA for support in this publication. Authors also thank to all interested colleagues for critical input on the approach and anonymous reviewers for helpful comments.
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