Anti-amnesic potentials of a novel phytochemical formulation PZA-3 in animal models relevant to Alzheimer's disease
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1
SET’s College of Pharmacy, India
Background: Dementia is one of the age related mental problems and a characteristic symptom of Alzheimer’s disease. There has been a steady rise in the number of patients suffering from Alzheimer’s disease (AD) all over the world. It is the most common form of onset of adult dementia and attention deficit disorders. Newer drugs are continually introduced into the market with little efficacy. Hence it is worthwhile to explore the utility of traditional medicines in treatment of cognitive disorders. The Indian system of medicine, Ayurveda has been in practice since 5000 years.
Objective: The main goal of the studies reported here is to investigate the cerebro-protective and memory improving potentials of phytochemicals based formulation PZA-3.
Methods: β-amyloid, scopolamine, ibotenic acid, CO2 and aging induced amnesia, KCN and Carotid artery ligation-induced hypoxia were the experimental models. Basal forebrain lesion induced decrease in cerebral Ach and ChAT activity were assessed, Concentrations of Norepinerphrine, Epinephrine, Dopamine, 5-HT in cerebral cortex, cerebellum, hypothalamus, hippocampus, and corpus striatum were measured by HPLC analysis. Neuromorphology, contents of MDA, NO, activities of SOA and CAT were also measured which indicated that PZA-3 protected the animals from stress, amnesia and neurodegeneration.
Results and Discussion: They inhibited KCN and Carotid artery ligation induced hypoxia, reversed amnesia and neurodegeneration and produced normalizing action on discrete regions of brain and controlled alterations in neurotransmitter levels due to neurodegeneration. They also decreased ChAT activity in the parietal cortex and inhibited decrease in Ach levels in both parietal and frontal cortex in amnesic rats. Hence PZA-3 can be of enormous use in the treatment of dementia of Alzheimer’s type and other neurodegenerative disorders.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Poster Presentation
Topic:
Animal Models of Cognition
Citation:
Hanumanthachar
J and
Disale
C
(2008). Anti-amnesic potentials of a novel phytochemical formulation PZA-3 in animal models relevant to Alzheimer's disease.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.077
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Received:
01 Dec 2008;
Published Online:
01 Dec 2008.
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Correspondence:
Joshi Hanumanthachar, SET’s College of Pharmacy, Karnataka, India, amanjoshi17@yahoo.com