Protective effect of naringin, a citrus flavonoid, against cognitive impairment and oxidative stress in an animal model of sporadic dementia of Alzheimer’s type
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1
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University , India
Present study was designed to evaluate the protective effects of naringin against the colchicine-induced cognitive impairment and oxidative stress in rats. Colchicine (15µg/5µl) was administered intracerebroventricularly in rats. Rats were treated with naringin (per se; 40 and 80 mg/kg, p.o.) daily for a period of 25 days beginning 4 days prior to colchicine injection. On the 14 and 21 day after colchicine administration, behavioral studies were by Morris water maze paradigm, elevated plus maze task and locomotion (photoactometer). The rats were sacrificed on the 22 day following the last behavioral test and various biochemical tests were performed to assess the extent of oxidative stress. Intracerebroventricular administration of colchicine resulted in poor retention of memory in Morris water maze, elevated plus maze task paradigms and caused marked oxidative damage. It also caused a significant decrease in the acetylcholinesterase activity. Chronic administration of naringin caused an improvement in the cognitive dysfunction and significantly reduced the elevated malondialdehyde, nitrite levels and restored sod, catalase, glutathione-s-transferase and acetylcholinesterase activity as well as the reduced glutathione levels. The results of the present study suggest the neuroprotective activity of naringin against colchicine-induced cognitive impairment and associated oxidative stress.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Poster Presentation
Topic:
Memory & Learning
Citation:
Kumar
A and
Dogra
S
(2008). Protective effect of naringin, a citrus flavonoid, against cognitive impairment and oxidative stress in an animal model of sporadic dementia of Alzheimer’s type.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.295
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Received:
09 Dec 2008;
Published Online:
09 Dec 2008.
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Correspondence:
Anil Kumar, Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, kumaruips@yahoo.com