The effect of methylphenidate on brain hemodynamics of attention-deficit hyperactivity disorder measured by functional near infrared spectroscopy
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1
Institute of Biomedical Engineering, Bogaziçi University, Türkiye
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2
Department of Child Psychiatry, SB Diskapi Children`s Hospital, Türkiye
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3
Department of Psychiatry, Ankara University School of Medicine, Türkiye
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4
Harvard Medical School, United States
Attention-deficit/hyperactivity disorder (ADHD) is a very common neurodevelopmental disorder. This neurobehavioral disorder results in significant functional impairment. It decreases the life quality of the patients. Therefore, the need for recognition and treatment of patients with ADHD is necessary. Methylphenidate (MPH) is known to reduce hyperactivity in individuals with ADHD. Yet little is known about how it alters neural activity and how this relates to its clinical effects. Functional Near-Infrared Spectroscopy (fNIRS) is a portable, non-invasive brain imaging method measuring the changes in oxygenated hemoglobin [HbO2] and deoxyhemoglobin [HbH] levels particularly in prefrontal cortex. In this study, 15 adult, right handed cases with DSM-IV diagnosis of Attention deficit hyperactivity disorder (ADHD) were evaluated with fNIRS during a cognitive task which is Stroop test. The goal of this study is to examine MPH-induced hemodynamic changes during a cognitive activity, and to examine how these changes correlate with measures of behavioral response to the drug during Stroop task. It is found that MPH effectively decreased HbO2 levels. The reason of the decreased level of HbO2 after medication is vasoconstriction. MPH normalized the behavior during an executive function test. MPH has a great effect on the response time of the subjects to neutral, congruent, and incongruent stimuli. MPH always shortens the durations of the reaction times.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Oral Presentation
Topic:
Neuropsychiatric Disorders
Citation:
Topaloglu
N,
Kara
E,
Karahan
E,
Erdogan
SB,
Serap
S,
Öner
O,
Öncü
B,
Münir
K,
Çiftçi
K and
Akin
A
(2008). The effect of methylphenidate on brain hemodynamics of attention-deficit hyperactivity disorder measured by functional near infrared spectroscopy.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.381
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Received:
16 Dec 2008;
Published Online:
16 Dec 2008.
*
Correspondence:
Nermin Topaloglu, Institute of Biomedical Engineering, Bogaziçi University, Istanbul, Türkiye, nermint@gmail.com