Visual mismatch negativity in Alzheimer’s disease and mild cognitive impairment.
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1
Department of Experimental Psychology, Bristol University, United Kingdom
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2
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital Headignton, United Kingdom
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3
The Burden Institute Frenchay Hospital, United Kingdom
In healthy ageing, the vMMN evoked in response to changes in the shape of visual stimuli is significantly reduced in amplitude, even absent, compared to young adults. However, the pattern of abnormality of the vMMN in relation to this visual feature in AD has been found to be qualitatively different from that in both young and older healthy adults. During the first half of a test session, Tales & Butler (2006) found that the AD group were like old controls in showing no significant vMMN, but as testing continued, the AD group revealed a robust and significant vMMN. The AD patients in this group were not receiving any medication. In a subsequent study Tales et al (2008) found that patients with mild cognitive impairment also showed significantly abnormal vMMN compared to healthy ageing. Furthermore, there is some evidence to indicate that treatment with cholinesterase inhibitors can affect the vMMN exhibited by patients with AD. In a subsequent study on healthy young adults we examine the effects of target probability on the magnitude of the vMMN and find it significantly reduced in response to an increase in the frequency of the deviant. We present this finding for discussion in relation to our findings in AD and MCI.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Oral Presentation
Topic:
Workshop 1: Visual Mismatch Negativity (vMMN)
Citation:
Tales
A,
Wilcock
G,
Porter
G and
Stuart
B
(2009). Visual mismatch negativity in Alzheimer’s disease and mild cognitive impairment..
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.032
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Received:
20 Mar 2009;
Published Online:
20 Mar 2009.
*
Correspondence:
Andreas Tales, Department of Experimental Psychology, Bristol University, Bristol, United Kingdom, Andrea.Tales@bristol.ac.uk