Are Pitch and Duration MMN Differentially Sensitive to the Schizophrenia Genotype? Evidence from First Hospitalized Psychosis Subjects
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1
Cognitive Neuroscience Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School, United States
Salisbury et al (2002, 2007) reported no significant pitch MMN reductions at first hospitalization for schizophrenia and Umbricht et al (2006) reported no significant pitch MMN or duration MMN reductions at first hospitalization for schizophrenia. However, there have been reports of both pitch and duration MMN reductions in family members, and, although rather speculative, in prodromal and ultra-high risk subjects. We examined both pitch and duration MMNs in a new cohort of first hospitalized schizophrenia-spectrum, psychotic bipolar disorder, and matched controls. The nose was used as reference. For pitch MMN, there were no differences between the 3 groups, replicating the lack of MMN reduction at first hospitalization. For duration MMN, suggested to be more sensitive to the schizophrenia genotype, there was no significant difference at Fz, with first hospitalized schizophrenia patients showing a robust response. Likewise, patients had normal duration MMN at inferior temporal sites with the expected polarity inversion. The duration MMN distribution was significantly more posterior than the pitch MMN, indicating a different generator configuration. The first hospitalized schizophrenia subjects showed significantly reduced duration MMN over posterior lateral parietal sites (unprotected t-SPM >3). Lesion data suggest right frontal and right parietal damage impair duration estimation. CSD analyses suggest posterior current sinks contributing to duration MMN may be impaired at first hospitalization. These results suggest that duration MMN may be selectively regionally impaired at first hospitalization. This impairment may not be due to temporal sources, but to posterior parietal generators implicated in the analysis of timing and duration. Because pitch MMN reduction may be endophenotypic of late maturational changes in the 3rd decade, it may prove impractical for gene discovery due to the loss of power and need to study only older subjects after progression would have occurred. If duration MMN regional deficits are stable, present at or before symptom onset, and confirmed in other samples, they may better aid in gene discovery due to the greater power engendered by the use of all (younger) subjects.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Oral Presentation
Topic:
Symposium 1: MMN as a potential endophenotype in schizophrenia
Citation:
Salisbury
DF and
McCarley
RW
(2009). Are Pitch and Duration MMN Differentially Sensitive to the Schizophrenia Genotype? Evidence from First Hospitalized Psychosis Subjects.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.036
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Received:
20 Mar 2009;
Published Online:
20 Mar 2009.
*
Correspondence:
Dean F Salisbury, Cognitive Neuroscience Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, United States, dean_salisbury@hms.harvard.ed