MMN to sound duration deviance during sleep
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1
INSERM U821, Brain Dynamics and Cognition, Université Lyon 1, France
How does the sleeping brain process external stimuli? Are low levels of sensory information processing functional during sleep? For example, is sensory memory maintained when we sleep? In order to address this issue, we investigated brain reactivity to simple auditory stimulations during sleep in 10 young healthy subjects. EEG signal was acquired continuously during a whole night of sleep while a classical oddball paradigm with duration deviance (p=0.14) was applied (simple tones: 800Hz, 50 dB SL; standard duration = 75ms; deviant duration = 30ms). We studied the difference event-related potential (ERP) between the rare (deviant) sound and the frequent (standard) sound. We searched for the presence of two different types of brain responses in this difference ERP: the Mismatch Negativity (MMN), which indexes sensory memory representations, and subsequent positive waves (frontal P3a and parietal P3b), which indicate attention orienting and other elaborated cognitive processing. In all sleep stages except sleep stage 4, a MMN was unquestionably found in response to deviant tones, revealing for the first time preserved sensory memory processing during almost the whole night. Unexpectedly, during sleep stage 2 and Rapid Eye Movement sleep (REM), both a P3a and a P3b-like component were identified after the MMN in the difference ERP, whereas a P3a alone followed the MMN in wakefulness and in sleep stage 1. This surprising result suggests elaborated processing of external stimulation during sleep. One may conclude from the P3a detection in stage 2 and REM sleep that an orientation of the subjects’ attention to the deviant tone is maintained even when he/she is deeply asleep. The P3b-like response could be associated to an active processing of the deviant tone in the dream’s consciousness, which may subserve the incorporation of external stimuli into dream.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster Presentations
Citation:
Ruby
P,
Caclin
A,
Boulet
S,
Delpuech
C and
Morlet
D
(2009). MMN to sound duration deviance during sleep.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.046
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Received:
24 Mar 2009;
Published Online:
24 Mar 2009.
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Correspondence:
Dominique Morlet, INSERM U821, Brain Dynamics and Cognition, Université Lyon 1, Lyon, France, dominique.morlet@inserm.fr