Control networks in Tourette Syndrome
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1
Washington University School of Medicine, Department of Neurology, United States
Tourette Syndrome (TS) is a pediatric neurological disorder characterized by unintended stereotyped, repetitive movements and vocalizations called tics. One hypothesis is that TS is the result of an impaired control system in the brain that is unable to prevent unwanted behaviors. To test this, we measured the correlations in resting state functional connectivity MRI (rs-fcMRI) between previously defined putative task control regions in the brains of adolescents with and without TS. Of particular interest were two networks hypothesized to be involved in task control: a cingulo-opercular network likely important for set-maintenance, and a fronto-parietal network likely involved in more rapid, adaptive online control. Additional functionally-defined networks were also examined. A variety of statistical measures and network level analysis tools were used to evaluate the resting-state functional connectivity of these regions in the TS group. The data from the TS group was explored in the context of typical developmental change, as well as in a direct comparison to an age-matched unaffected group. Results indicated that the TS group showed widespread immaturity of functional connections in control-related regions, with additional, more profound deviation of connectivity to and among frontal and parietal regions related to adaptive control. These findings suggest that both delayed and atypical development of task control networks may be characteristic of TS.
Conference:
Conference on Neurocognitive Development, Berkeley, CA, United States, 12 Jul - 14 Jul, 2009.
Presentation Type:
Oral Presentation
Topic:
Cognitive control frontostriatal circuitry, and dopamine
Citation:
Church
J
(2009). Control networks in Tourette Syndrome.
Conference Abstract:
Conference on Neurocognitive Development.
doi: 10.3389/conf.neuro.09.2009.10.015
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Received:
06 Jul 2009;
Published Online:
06 Jul 2009.
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Correspondence:
Jessica Church, Washington University School of Medicine, Department of Neurology, St. Louis, United States, jess@npg.wustl.edu