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Killer B Lymphocytes and Their Fas Ligand Positive Exosomes as Inducers of Immune Tolerance

Steven Karl Lundy, Matthew W Klinker and David A Fox

Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing the natural...

Front. Immunol. doi: 10.3389/fimmu.2015.00122
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Adaptations of Natural Killer Cells to Self-MHC Class I

Stéphanie Bessoles, Camille Grandclément, Elisenda Alari-Pahissa, Jasmine Gehrig, Beena Jeevan-Raj and Werner Held

Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence...

Front. Immunol. doi: 10.3389/fimmu.2014.00349
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Extracellular Adenosine-Mediated Modulation of Regulatory T Cells

Akio Ohta and Michail Sitkovsky

Extracellular adenosine-dependent suppression and redirection of pro-inflammatory activities is mediated by the signaling through adenosine receptors on the surface of most immune cells. The immunosuppression by...

Front. Immunol. doi: 10.3389/fimmu.2014.00304

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