The role of mitochondria in yeast programmed cell death
- 1Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, Italy
- 2Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features including reactive oxygen species production, protease activity and a major role played by mitochondria. In view of this, and of the distinctive characteristics differentiating yeast and multicellular organism PCD, the mitochondrial contribution to cell death in the genetically tractable yeast Saccharomyces cerevisiae has been intensively investigated. In this mini-review we report whether and how yeast mitochondrial function and proteins belonging to oxidative phosphorylation, protein trafficking into and out of mitochondria, and mitochondrial dynamics, play a role in PCD. Since in PCD many processes take place over time, emphasis will be placed on an experimental model based on acetic acid-induced PCD (AA-PCD) which has the unique feature of having been investigated as a function of time. As will be described there are at least two AA-PCD pathways each with a multifaceted role played by mitochondrial components, in particular by cytochrome c.
Keywords: yeast, programmed cell death, mitochondria, acetic acid, cytochrome c, protein trafficking, intracellular signaling
Citation: Guaragnella N, Ždralević M, Antonacci L, Passarella S, Marra E and Giannattasio S (2012) The role of mitochondria in yeast programmed cell death. Front. Oncol. 2:70. doi: 10.3389/fonc.2012.00070
Received: 05 April 2012; Accepted: 14 June 2012;
Published online: 03 July 2012.
Copyright: © 2012 Guaragnella, Ždralević, Antonacci, Passarella, Marra and Giannattasio. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Sergio Giannattasio, Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Via Amendola 165/A, I-70126 Bari, Italy. e-mail: firstname.lastname@example.org