• Info
  • Home
  • About
  • Editorial Board
  • Archive
  • Research Topics
  • View Some Authors
  • Review Guidelines
  • Subscribe to Alerts
  • Search
  • Article Type

    Publication Date

  • Author Info
  • Why Submit?
  • Fees
  • Article Types
  • Author Guidelines
  • Submission Checklist
  • Contact Editorial Office
  • Submit Manuscript
Start date should be earlier than end date. OK Please enter the date in dd/mm/yyyy format or use the calendar icon to the left of the date field.

Research Topic

Share 0
Like 0

Targeted Radionuclide Therapy in Oncology

Topic Editors:

Jean-Pierre POUGET, INSERM, France

Submission Closed.

Targeted radionuclide therapy (TRT) is an attractive tool for specifically deliver radiation to diffuse, primary or metastatic cancer cells in close vicinity to risk organs. It is a multidisciplinary approach that requires the collaboration of biologists, physicists, chemists, radiation oncologists and nuclear medicine physicians. During the last 50 years, advances in molecular biology have provided a wide panel of vectors against tumor cells, while improvement in radiation chemistry together with a wide isotope supply have considerably increased the number of radiolabeled molecules that are now available for preclinical and clinical studies. These progresses have led to the approval of two specialties for the treatment of the radiation-sensitive non-Hodgkin B lymphoma. However, the treatment of the radio-resistant solid tumors requires more complex and tailored approaches. Besides the choice of the most relevant clinical target and of the most appropriate vector and isotopes, TRT cannot be any longer based solely on a pharmacological approach, but requires tailored treatments founded on dose regimens and dose-effect relationship. Molecular imaging will play a central role in predicting the expression of targets, the behavior of the injected molecules and the assessment of the absorbed dose for a personalized dosimetry. A better understanding of the radiation-induced biological effects (radiobiology) of low dose-rate targeted radionuclide therapy needs to be investigated to provide TRT with the necessary knowledge for the successful use of radiation and the optimization of therapeutic combinations. In this Frontiers Research Topic, we encourage submission of original papers and reviews dealing with basic, translational and clinical research in targeted radionuclide therapy.

Share 0
Like 0

About Frontiers Research Topics


Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

© 2007 - 2014 Frontiers Media S.A. All Rights Reserved