TY - JOUR AU - Gillet, Shea N. AU - Kato, Hiroyuki K. AU - Justen, Marissa A. AU - Lai, Mandy AU - Isaacson, Jeffry S. PY - 2018 M3 - Original Research TI - Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation JO - Frontiers in Neural Circuits UR - https://www.frontiersin.org/articles/10.3389/fncir.2017.00112 VL - 11 SN - 1662-5110 N2 - Projections from auditory cortex to the amygdala are thought to contribute to the induction of auditory fear learning. In addition, fear conditioning has been found to enhance cortical responses to conditioned tones, suggesting that cortical plasticity contributes to fear learning. However, the functional role of auditory cortex in the retrieval of fear memories is unclear and how fear learning regulates cortical sensory representations is not well understood. To address these questions, we use acute optogenetic silencing and chronic two-photon calcium imaging in mouse auditory cortex during fear learning. Longitudinal imaging of neuronal ensemble activity reveals that discriminative fear learning modulates cortical sensory representations via the suppression of cortical habituation. ER -