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Original Research ARTICLE

Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis

Dumitru A. Iacobas¹*, Sanda Iacobas¹, Peter Werner², ElianaScemes¹ and David C. Spray¹

¹ Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, USA
² Departments of Neurology and Pathology (Neuropathology), Albert Einstein College of Medicine, USA

Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE) is an inflammatory demyelination that recapitulates in mouse spinal cord (SC) the human multiple sclerosis disease. We now analyze previously reported cDNA array data from age-matched young female adult control and passively myelin antigen-sensitized EAE mice with regard to organizational principles of the SC transcriptome in autoimmune demyelination. Although AT-EAE had a large impact on immune response genes, broader functional and chromosomal gene cohorts were neither significantly regulated nor showed significant changes in expression coordination. However, overall transcriptional control was increased in AT-EAE and the proportions of transcript abundances were perturbed within each cohort. Striking likenesses and oppositions were identified in the coordination profiles of genes related to myelination, calcium signaling, and inflammatory response in controls that were substantially altered in AT-EAE. We propose that up- or down-regulation of genes linked to those targeted by the disease could potentially compensate for the pathological transcriptomic changes.

Keywords: autoimmune demyelination, calcium signaling, chemokines, cytokines, EAE, inflammatory response, multiple sclerosis, myelination

Citation: Dumitru A. Iacobas, Sanda Iacobas, Peter Werner, Eliana Scemes and David C. Spray (2007). Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis. Front. Integr. Neurosci. 1:10. doi: 10.3389/neuro.07/010.2007

Received: 10 October 2007; Paper pending published: 13 December 2007;
Accepted: 3 December 2007; Published online: 30 December 2007.

Edited by:

Sidney A. Simon, Duke University Medical Center, USA

Reviewed by:

Sidney A. Simon, Duke University, USA
Oscar Alzate, Duke University Medical Center, USA

Copyright: © 2007 Iacobas, Iacobas, Werner, Scemes and Spray. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

*Correspondence: Dumitru Andrei Iacobas, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. e-mail: diacobas@aecom.yu.edu

Abbreviations: AT-EAE, adoptive transfer experimental autoimmune encephalomyelitis; CSD, cell cycle, shape, differentiation, death; CYT, cytoskeleton; EAE, experimental autoimmune encephalomyelitis; ENE, energy metabolism; GES, gene expression stability; JAE, cell junction, adhesion, extracellular matrix; MS, multiple sclerosis; REV, relative estimated (transcription) variability; RNA, RNA processing; SIG, cell signaling; TIC, transport of small molecules and ions into or out of the cells; TRA, transcription; TWC, transport of ionsmolecules within the cells; UNK, function not yet assigned