Original Research ARTICLE

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Performance- and stimulus-dependent oscillations in monkey prefrontal cortex during short-term memory

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Abteilung Neurophysiologie, Max-Planck-Institut für Hirnforschung, Frankfurt/M, Germany
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Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, Frankfurt/M, Germany
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University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD, USA
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Department of Psychology, University of Glasgow, Centre for Cognitive Neuroimaging, Glasgow, UK
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Brain Imaging Center Frankfurt, Johann Wolfgang Goethe Universität, Frankfurt/M, Germany
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Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Maastricht, The Netherlands
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Abteilung Physiologie kognitiver Prozesse, Max-Planck-Institute für biologische Kybernetik, Tübingen, Germany
Short-term memory requires the coordination of sub-processes like encoding, retention, retrieval and comparison of stored material to subsequent input. Neuronal oscillations have an inherent time structure, can effectively coordinate synaptic integration of large neuron populations and could therefore organize and integrate distributed sub-processes in time and space. We observed field potential oscillations (14–95 Hz) in ventral prefrontal cortex of monkeys performing a visual memory task. Stimulus-selective and performance-dependent oscillations occurred simultaneously at 65–95 Hz and 14–50 Hz, the latter being phase-locked throughout memory maintenance. We propose that prefrontal oscillatory activity may be instrumental for the dynamical integration of local and global neuronal processes underlying short-term memory.
Keywords:
visual short-term memory, prefrontal cortex, local field potential, behavioral performance, stimulus coding
Citation:
Pipa G, Städtler ES, Rodriguez EF, Waltz JA, Muckli LF, Singer W, Goebel R and Munk MHJ (2009). Performance-and stimulus-dependent oscillations in monkey prefrontal cortex during short-term memory. Front. Integr. Neurosci. 3:25. doi: 10.3389/neuro.07.025.2009
Received:
01 March 2009;
 Paper pending published:
20 April 2009;
Accepted:
09 September 2009;
 Published online:
07 October 2009.

Edited by:

Rui M. Costa, Instituto Gulbenkian de Ciência, Portugal

Reviewed by:

Gregor Rainer, Max Planck Institute for Biological Cybernetics, Germany
Steven Bressler, Florida Atlantic University, USA
Copyright:
© 2009 Pipa, Städtler, Rodriguez, Waltz, Muckli, Singer, Goebel and Munk. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
*Correspondence:
Matthias H. J. Munk, Department Physiology of Cognitive Processes, Max-Planck-Institute for Biological Cybernetics, Spemannstraße 38, 72076 Tübingen, Germany. e-mail: matthias.munk@tuebingen.mpg.de
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