AUTHOR=Lopez-Medina Marcela , Perez-Lopez Araceli , Alpuche-Aranda Celia , Ortiz-Navarrete Vianney 

TITLE=Salmonella Modulates B Cell Biology to Evade CD8+ T Cell-Mediated Immune Responses

JOURNAL=Frontiers in Immunology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00586

DOI=10.3389/fimmu.2014.00586

ISSN=1664-3224

ABSTRACT=<p>Although B cells and antibodies are the central effectors of humoral immunity, B cells can also produce and secrete cytokines and present antigen to helper T cells. The uptake of antigen is mainly mediated by endocytosis; thus, antigens are often presented by MHC-II molecules. However, it is unclear if B cells can present these same antigens via MHC-I molecules. Recently, <italic>Salmonella</italic> bacteria were found to infect B cells, allowing possible antigen cross-processing that could generate bacterial peptides for antigen presentation via MHC-I molecules. Here, we will discuss available knowledge regarding <italic>Salmonella</italic> antigen presentation by infected B cell MHC-I molecules and subsequent inhibitory effects on CD8<sup>+</sup> T cells for bacterial evasion of cell-mediated immunity.</p>