AUTHOR=Guimaraes Allan J., de Cerqueira Mariana D., Nosanchuk Joshua D.

TITLE=Surface Architecture of Histoplasma Capsulatum

JOURNAL=Frontiers in Microbiology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00225

DOI=10.3389/fmicb.2011.00225

ISSN=1664-302X

ABSTRACT=<p>The dimorphic fungal pathogen <italic>Histoplasma capsulatum</italic> is the most frequent cause of clinically significant fungal pneumonia in humans. <italic>H. capsulatum</italic> virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with <italic>H. capsulatum</italic> pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of <italic>H. capsulatum</italic> that have been associated with virulence and discuss their involvement in the pathobiology of disease.</p>