AUTHOR=Hornik Alejandro , Rodriguez-Porcel Federico , Wallery Shawn , Flaster Murray , Lee John , Biller Jose 

TITLE=Late Onset CNS Immune Reconstitution Inflammatory Syndrome in an Immunocompetent Patient

JOURNAL=Frontiers in Neurology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2013.00012

DOI=10.3389/fneur.2013.00012

ISSN=1664-2295

ABSTRACT=<p>Immune reconstitution inflammatory syndrome (IRIS) refers to the presence of paradoxical clinical deterioration attributable to immune system recovery during highly active antiretroviral therapy (HAART). We present an immunocompetent patient with multifocal leukoencephalopathy on HAART, with central nervous system (CNS) IRIS pathology of unknown infectious etiology. CNS IRIS pathology should be suspected in patients on longstanding HAART without immune reconstitution, presenting with unexplained leukoencephalopathy.</p>