AUTHOR=Mackowiak Philip A.

TITLE=Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life

JOURNAL=Frontiers in Public Health

VOLUME=1

YEAR=2013

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2013.00052

DOI=10.3389/fpubh.2013.00052

ISSN=2296-2565

ABSTRACT=<p>Over a century ago, Elie Metchnikoff theorized that health could be enhanced and senility delayed by manipulating the intestinal microbiome with host-friendly bacteria found in yogurt. His theory flourished for a time, then drifted to the fringe of medical practice before re-emerging in the mid-1990s as a concept worthy of mainstream medical attention. Metchnikoff also predicted the existence of bacterial translocation and anticipated theories linking chronic inflammation with the pathogenesis of atherosclerosis and other disorders of the aged.</p>