1
Department of Physiology, Northwestern University, Chicago, IL, USA
2
Department of Neuroscience and Brain Technologies, Italian Institute of Technology, Genova, Italy
3
Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA
4
Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA
5
Rehabilitation Institute of Chicago, Chicago, IL, USA
A critical advance for brain–machine interfaces is the establishment of bi-directional communications between the nervous system and external devices. However, the signals generated by a population of neurons are expected to depend in a complex way upon poorly understood neural dynamics. We report a new technique for the identification of the dynamics of a neural population engaged in a bi-directional interaction with an external device. We placed in vitro preparations from the lamprey brainstem in a closed-loop interaction with simulated dynamical devices having different numbers of degrees of freedom. We used the observed behaviors of this composite system to assess how many independent parameters − or state variables − determine at each instant the output of the neural system. This information, known as the dynamical dimension of a system, allows predicting future behaviors based on the present state and the future inputs. A relevant novelty in this approach is the possibility to assess a computational property – the dynamical dimension of a neuronal population – through a simple experimental technique based on the bi-directional interaction with simulated dynamical devices. We present a set of results that demonstrate the possibility of obtaining stable and reliable measures of the dynamical dimension of a neural preparation.