I began my research career in 1976 at the Cajal Institute, under the supervision of Dr. J. Rodrigo, experimentally and morphologically studying the sympathetic and parasympathetic innervation of the mammalian oesophagus. Having presented my doctoral thesis in 1980, I joined the laboratory of Drs F. Valverde and A. Fairén at the same Institute. It was in this period that I began to study the microorganization of the cerebral cortex, using the combined method of Golgi-electron microscopy, a subject that has remained the focal point for my research since then. During this period, we developed a very simple and effective method for correlative light and electron microscopic studies to analysis the connections between identified neurons at the electron microscopy level. This method allowed us to identify unequivocally every part of the axon and the dendrites of the cell under study. In 1983, I obtained a Fogarty Fellowship (NIH) to work with Dr. Edward Jones at the Washington University School of Medicine, St. Louis (USA). This allowed me to extend my studies on cortical organization through the use of additional methods, such as high resolution immunocytochemistry and the use of anatomical tracers. One of the most important scientific achievements was the demonstration of the coexistence of neuropeptides (somatostatin, neuropeptide Y and cholecystokinin) with a classical neurotransmitter (GABA) in the cerebral cortex. From 1984 to 1985 I was appointed as a Visiting Scientist, in the laboratory of Dr. Jones at the University of California (Irvine). After this period in the laboratory of the Dr. Jones (1983-1986), I obtained a Tenured in Neuroscience at the Cajal Institute to continue my research on the cerebral cortex. Between 1989 and 1991, I returned to Dr. Jones’ laboratory to study the microorganization of the monkey cerebral cortex. In 1991 I returned to the Cajal Institute to establish a research group that principally focuses on the microorganization of the normal cerebral cortex (including hippocampus) in various species (particularly humans) and on the alterations of cortical circuits in epilepsy and Alzheimer disease. In 2000, I was appointed as Research Scientist, and in 2004 as Full Professor in the same institution. Another of my principal interest is the study of the history of our current understanding of cortical organization and function. In particular, I am interested in the roots of cortical histology and circuitry. At present I am director of the Laboratorio Cajal de Circuitos Corticales (Centro de Tecnología Biomédica, UPM) and of the Laboratorio de Microorganización de la Corteza Cerebral Normal y Alteraciones de los Circuitos (Departamento de Neurobiología Funcional y de Sistemas, Instituto Cajal, CSIC).

CONTACT INFORMATION

Professional Address
Cajal Institute
Madrid, Spain

PROFESSIONAL EXPERTISE

Science > Neuroscience > Neuroanatomy
Health

POSITIONS

Full Professor
Jan 2004 - Current
Cajal Institute
Madrid, Spain
Research Scientist
Jan 2000 - Jan 2004
Cajal Institute
Madrid, Spain
Tenured Scientist
Jan 1991 - Jan 2000
Cajal Institute
Madrid, Spain
Research Assistant
Jan 1989 - Jan 1991
University of California Irvine Campus
California, USA
Tenured Scientist
Jan 1986 - Jan 1989
Cajal Institute
Madrid, Spain
Visiting Scientist
Jan 1984 - Jan 1985
University of California Irvine Capmpus
California, USA
Fellow
Jan 1983 - Jan 1984
Washington University School of Medicine
St. Louis, MO, USA
Fellow
Jan 1980 - Jan 1983
Cajal Institute / Department of Neuroanatomy
Madrid, Spain
Fellow
Jan 1978 - Jan 1980
Cajal Institute
Madrid, Spain

EDUCATION

Italian System
Jan 1975Current
Universidad Complutense
Madrid, Spain
PhD
Jan 1977 - Jan 1979
Health > Astronomy and Space Sciences
Universidad Complutense
Madrid, Spain
Masters
Jan 1975 - Jan 1977
Health
Universidad Complutense
Madrid, Spain

HONORS & AWARDS

Pfizer (SEEN) award
  2004
Awarding Authority:
Pfizer
National Alliance for Autism Research Award
  2003
Awarding Authority:
Ramón Trias Fargas
National Alliance for Autism Research Award
  2000
Awarding Authority:
USA
Cajal Medal for excellence in research
  1999
Awarding Authority:
Cajal Club
Krieg cortical Kudos discoverer award
  1999
Awarding Authority:
Cajal Club
Delta Award
  1997
Awarding Authority:
Tres Cantos, Madrid
Fundación Eugenio Rodriguez Pascual Award
  1992
Awarding Authority:
Fundación Eugenio Rodriguez

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