is a specialty section of Frontiers in Bioengineering and Biotechnology, Frontiers in Cell and Developmental Biology, Frontiers in Genetics, Frontiers in Neuroscience, Frontiers in Physiology and Frontiers in Psychiatry.
This is an interdisciplinary section that features the modelling and discovering of emergent properties in complex biological systems. One of the main objectives is to relate the structure and dynamics of biological systems with their physiology and phenotypic traits through an approach that integrates theoretical models, computational analysis and empirical data. Such analysis can be conducted at any scale of biological organization, ranging from single cells to ecological systems. Contrary to the reductionist paradigm commonly used in Molecular Biology, in Systems Biology the understanding of the behaviour and evolution of complex biological systems need not necessarily be based on a detailed molecular description of the interactions between the system’s constituent parts. Therefore, we welcome Systems Biology research with or without underlying molecular mechanisms justifying the system-level description. Translation of system-level approaches into computer-aided diagnosis and treatment of disease, health-maintenance interventions, and the clinical practice are also welcome.
The scope of the section embraces a wide range of topics in systems biology, physiology, and medicine, including (but not limited to): dynamics and evolution of metabolic and gene regulatory networks, integrative and computational neuroscience, evolutionary genomics, cell dynamics, organismal development, computational biology, ecosystem dynamics, integrative and behavioural medicine, etc. The section's main focus is on analytical and computational models that are strongly supported and inspired by real biological systems and that integrate current empirical knowledge. Work presenting experimental data without a theoretical or computational modelling component will not be considered and neither will work with theoretical models only tangentially inspired by biological systems.
Systems Biology now covers the section "Systems Physiology", which was discontinued from "Frontiers in Physiology" in August 2012.
welcomes submissions of the following tier 1 articles
: Book Review, Clinical Case Study, Clinical Trial, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Specialty Grand Challenge and Technology Report.
All manuscripts must be submitted directly to the section Systems Biology
, where they are peer reviewed by the associate and review editors of the specialty section.
Articles published in the section Systems Biology
will be subject to the Frontiers evaluation system
after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a prestigious Frontiers Focused Review
- a tier 2 article. This is referred to as "democratic tiering
". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Bioengineering and Biotechnology, Cell and Developmental Biology, Genetics, Neuroscience, Physiology and Psychiatry.