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Specialty Chief Editor/s:  Hiroaki Kitano, The Systems Biology Institute, Japan
Aldana Maximino, Universidad Nacional Autónoma de México, Mexico
Raina Robeva, Sweet Briar College, USA

Indexed in: PubMed, PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS)

PMCID: all published articles receive a PMCID

Mission Statement

Systems Biology is a specialty section of Frontiers in Bioengineering and Biotechnology, Frontiers in Cell and Developmental Biology, Frontiers in Genetics, Frontiers in Neuroscience, Frontiers in Physiology and Frontiers in Psychiatry.

This is an interdisciplinary Specialty that features the modelling and discovery of emergent properties in complex biological systems. One of the main objectives is to relate the structure and dynamics of biological systems with their physiology and phenotypic traits through an approach that integrates theoretical models, computational analysis and empirical data. Such analysis can be conducted at any scale of biological organization, ranging from single cells to ecological systems. Contrary to the reductionist paradigm commonly used in Molecular Biology, in Systems Biology the understanding of the behaviour and evolution of complex biological systems need not necessarily be based on a detailed molecular description of the interactions between the system’s constituent parts. Therefore, we welcome Systems Biology research with or without underlying molecular mechanisms justifying the system-level description. Translation of system-level approaches into computer-aided diagnosis and treatment of disease, health-maintenance interventions, and the clinical practice are also welcome.

The scope of the section embraces a wide range of topics in systems biology, physiology, and medicine, including (but not limited to): dynamics and evolution of metabolic and gene regulatory networks, integrative and computational neuroscience, evolutionary genomics, cell dynamics, organismal development, computational biology, ecosystem dynamics, integrative and behavioural medicine, etc. The section's main focus is on analytical and computational models that are strongly supported and inspired by real biological systems and that integrate current empirical knowledge. Work presenting experimental data without a theoretical or computational modelling component will not be considered and neither will work with theoretical models only tangentially inspired by biological systems.

Systems Biology now covers the section "Systems Physiology", which was discontinued from "Frontiers in Physiology" in August 2012.

Systems Biology welcomes submissions of the following tier 1 articles: Book Review, Clinical Case Study, Clinical Trial, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Protocols, Review, Specialty Grand Challenge and Technology Report.

All manuscripts must be submitted directly to the section Systems Biology, where they are peer reviewed by the associate and review editors of the specialty section.

Articles published in the section Systems Biology will be subject to the Frontiers evaluation system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a prestigious Frontiers Focused Review - a tier 2 article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Bioengineering and Biotechnology, Cell and Developmental Biology, Genetics, Neuroscience, Physiology and Psychiatry.

Open Access Statement

Frontiers’ philosophy is that all research is for the benefit of humankind. Research is the product of an investment by society and therefore its fruits should be returned to all people without borders or discrimination, serving society universally and in a transparent fashion.

That is why Frontiers provides online free and open access to all of its research publications. For more information on open access click here.

Copyright Statement

Under the Frontiers Conditions for Website Use and the Frontiers General Conditions for Authors, authors of articles published in Frontiers journals retain copyright on their articles, except for any third-party images and other materials added by Frontiers, which are subject to copyright of their respective owners. Authors are therefore free to disseminate and re-publish their articles, subject to any requirements of third-party copyright owners and subject to the original publication being fully cited. Visitors may also download and forward articles subject to the citation requirements and subject to any fees Frontiers may charge for downloading licenses. The ability to copy, download, forward or otherwise distribute any materials is always subject to any copyright notices displayed. Copyright notices must be displayed prominently and may not be obliterated, deleted or hidden, totally or partially. A charge may be made for some facilities (such as downloading of e-magazines), where stated.


Each Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Frontiers is well aware of the potential impact of published research both on future research and on society and, hence, does not support superficial review, light review or no-review publishing models. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public - and shape society. Therefore, Frontiers only applies the most rigorous and unbiased reviews, established in the high standards of the Frontiers Review System. Furthermore, only the top certified research, evaluated through the democratic Frontiers Evaluation System, is disseminated to increasingly wider communities as it gradually climbs the tiers of the Frontiers Tiering System from specialized expert readership towards public understanding.


Specialty Chief Editor/s:  Hiroaki Kitano, The Systems Biology Institute, Japan
Aldana Maximino, Universidad Nacional Autónoma de México, Mexico
Raina Robeva, Sweet Briar College, USA

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